@article{Câmara Mariz_de Moura Barros_de Oliveira Martins_Lopes Bressan_2021, title={Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis}, volume={79}, url={https://revista.spdv.com.pt/index.php/spdv/article/view/1287}, DOI={10.29021/spdv.79.1.1287}, abstractNote={<p><strong>Introduction</strong>: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD.</p> <p><strong>Material and Methods</strong>: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment).</p> <p><strong>Results</strong>: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them.</p> <p><strong>Conclusion</strong>: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.</p&gt;}, number={1}, journal={Journal of the Portuguese Society of Dermatology and Venereology}, author={Câmara Mariz, Juliana and de Moura Barros, Norami and de Oliveira Martins, Bárbara and Lopes Bressan, Aline}, year={2021}, month={Apr.}, pages={37-40} }