TY - JOUR AU - Laura V. Langer AU - Lucas Prim AU - Thelma Skare AU - Virginia Wrublevski AU - Renato Nisihara PY - 2021/10/17 Y2 - 2024/03/28 TI - Isotretinoin, Acne and Depression: A Prospective Controlled Study JF - Journal of the Portuguese Society of Dermatology and Venereology JA - SPDV VL - 79 IS - 3 SE - Original Articles DO - 10.29021/spdv.79.3.1373 UR - https://revista.spdv.com.pt/index.php/spdv/article/view/1373 AB - Introduction: Acne and isotretinoin, one of its treatment, have been linked to the occurrence of depression. Our aim was to study if isotretinoin is associated with depression in a sample of acne patients followed for 6 months comparing them with acne patients under other treatment modalities and control patients without acne.Methods: One hundred individuals were included: 50 controls and 50 with acne (24 using and 26 not using isotretinoin). Patients and controls answered the Beck Depression Inventory (BDI) and the 12 Item-Short Form Health Survey for quality of life (SF-12). Acne patients repeated this evaluation in 90 and 180 days.Results: No differences were found between controls and acne patients regarding BDI results but controls performed worse in the SF-12 mental domain (p=0.004). No differences were found within the acne group between those treated and not treated with isotretinoin in the comparison of the BDI and SF-12 (mental and physical domains) in days 0. 90 and 180 (all with p>0.05).Conclusion: In this small sample isotretinoin treatment showed to be safe regarding the occurrence of depression. ER -