TY - JOUR AU - Ana Gameiro AU - Inês Coutinho AU - José Carlos Cardoso AU - Américo Figueiredo PY - 2015/07/01 Y2 - 2024/03/29 TI - INFECTIOUS THROMBOTIC VASCULOPATHY JF - Journal of the Portuguese Society of Dermatology and Venereology JA - SPDV VL - 73 IS - 2 SE - Case Reports DO - 10.29021/spdv.73.2.381 UR - https://revista.spdv.com.pt/index.php/spdv/article/view/381 AB - Vasculitis is characterized by blood vessel inflammation, resulting in their damage or even complete destruction, and may lead to either ischemic or hemorrhagic presentations. Infection is a common cause of vasculitis, usually by deposition of immune complexes, complement activation and endotoxins. Less often, endocarditis or sepsis, due to embolization and direct invasion, can cause vasculitis. We present a 35 year-old woman, with purpuric and necrotic lesions, showing a relapsing course during several months. Complementary workup revealed cardiac vegetations, which were considered the most likely etiology for cutaneous manifestations. However, based on ethical/ religious concerns, the patient refused surgical treatment and died. This case represents a rare and exuberant clinical presentation of a thrombotic vasculopathy, probably caused by septic embolism from staphylococcal endocarditis. ER -