TY - JOUR AU - Francisco Ronaldo Moura Filho AU - Aline Guimarães Grana AU - Aline do Amaral Silva AU - Suzi Marla Carvalho Maron AU - Bárbara Rodovalho AU - Fabio Francesconi PY - 2016/12/26 Y2 - 2024/03/29 TI - Nodulosis by the use of the Methotrexate in Patient with Rheumatoid Arthritis JF - Journal of the Portuguese Society of Dermatology and Venereology JA - SPDV VL - 74 IS - 4 SE - Case Reports DO - 10.29021/spdv.74.4.679 UR - https://revista.spdv.com.pt/index.php/spdv/article/view/679 AB - Extra-articular manifestations in patients with rheumatoid arthritis are common. Subcutaneous nodules appear in almost 8% of users of methotrexate with rheumatoid arthritis. Methotrexate, one of the recommended drugs in this disease, may cause unwanted effects such as accelerated nodulosis. This complication is an important differential diagnosis in subcutaneous nodules rapidly evolving in rheumatoid arthritis patients on methotrexate and TNF inhibitors. Early diagnosis is essential for a forehand treatment. We describe a case of accelerated nodulosis associated with the use methotrexate and etanercept in patients with rheumatoid arthritis. ER -