TY - JOUR AU - Katarína Kieselová AU - Felicidade Santiago AU - Sofia Ramos AU - Maria Fernanda Cunha AU - Martinha Henrique PY - 2018/01/26 Y2 - 2024/03/28 TI - Cutaneous Lesions as the First Manifestation of Multiple Myeloma: Two Case Reports JF - Journal of the Portuguese Society of Dermatology and Venereology JA - SPDV VL - 75 IS - 4 SE - Case Reports DO - 10.29021/spdv.75.4.753 UR - https://revista.spdv.com.pt/index.php/spdv/article/view/753 AB - Multiple myeloma is a proliferative clonal disorder of plasma cells. The clinical presentation is highly variable, with recurrent infections, anemia, renal insufficiency or bone pain from osteolytic lesions as the main initial manifestations. Skin manifestations are unusual and mostly unspecific. We describe two patients with cutaneous lesions as the first sign of this hematologic malignancy: nodular deposits of amyloid in the external ear duct and diffuse plane xanthoma. ER -