Evaluation of Depression and Anxiety Disorders and Correlation with the Treatment of Patients with Psoriasis Vulgaris

Adriana Kamilly Leitão Pitman Machado; Caio Vinicius Botelho Brito; João Augusto Gomes de Souza Monteiro de Brito; Carla Andrea Avelar Pires; Francisca Regina Oliveira Carneiro

doi:10.29021/spdv.78.4.1224

Adriana Kamilly Leitão Pitman Machado Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil https://orcid.org/0000-0003-1490-2470
Caio Vinicius Botelho Brito Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil https://orcid.org/0000-0001-8381-2941
João Augusto Gomes de Souza Monteiro de Brito Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil https://orcid.org/0000-0001-7286-7066
Carla Andrea Avelar Pires Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil https://orcid.org/0000-0002-0566-9921
Francisca Regina Oliveira Carneiro Center of Biological and Health Sciences, State University of Pará, Belém, Pará, Brazil https://orcid.org/0000-0001-6735-4004

DOI: https://doi.org/10.29021/spdv.78.4.1224

Keywords: Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Psoriasis/complications, Psoriasis/psychology

Abstract

Introduction: Psoriasis is a chronic inflammatory multisystemic disease with several comorbidities, namely anxiety and depression disorders.

Methods: In this study, the prevalence of these psychiatric entities was investigated by the PHQ-9 and GAD-7 questionnaries and related to the socio-demographic variables and to the forms of clinical treatment.

Results: A total of 90 patients (56 females) were analyzed. Of these, 41 patients (45.56%) used topical treatment only, 28 patients (31.11%) used oral methotrexate and 21 patients (23.33%) used immunobiological agents (anti-TNF-alfa agents). It was observed that 47 patients (52.23%) presented some degree of depression (mild, moderate or severe) and 53 patients (58.89%) presented some degree of anxiety disorder (mild, moderate or severe). There was no statistical relationship between the anxiety and depression scores and the PASI score, as well as age, employability or schooling. There was a statistical association between psychiatric comorbidities and the female gender (p <0.0001). It was also observed a lower prevalence of depression (p = 0.0336) on patients using immunobiological treatments.

Conclusion: The findings confirm published data, showing association of psychiatric conditions with psoriasis, especially in relation to TNF-alpha, so that anti-TNF therapies may become an alternative for the treatment of depression or anxiety disorders associated with psoriasis.

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