Pigmented Epithelioid Melanocytoma: Case Report

Eduardo Scardazzi Silva Ragni; Marcel  Arakaki Asato; Estela  Mari Sandini; Lucas  Basmage Pinheiro Machado; Sylka  Rebelato Toppan

doi:10.29021/spdv.79.1.1269

Eduardo Scardazzi Silva Ragni Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Dermatologia, Campo Grande, Brasil
Marcel Arakaki Asato Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Dermatologia, Campo Grande, Brasil; Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Patologia, Campo Grande, Brasil
Estela Mari Sandini Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Dermatologia, Campo Grande, Brasil
Lucas Basmage Pinheiro Machado Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Dermatologia, Campo Grande, Brasil
Sylka Rebelato Toppan Universidade Federal do Mato Grosso do Sul – Faculdade de Medicina - Departamento de Dermatologia, Campo Grande, Brasil

DOI: https://doi.org/10.29021/spdv.79.1.1269

Keywords: Child, Melanoma, Nevus, Blue, Nevus, Pigmented, Skin Neoplasms

Abstract

Pigmented epithelioid melanocytoma is a rare, newly described melanocytic tumor that encompasses lesions previously classified as animal type melanomas and epithelioid blue nevus of the Carney complex. Pigmented epithelioid melanocytoma is a specific clinicopathological entity with particular clinical presentation and histological features. We present the case of a 5 year old female patient with a heavily pigmented papule on her right thigh that showed histological findings compatible with pigmented epithelioid melanocytoma and discuss the relevance /clinical significance of sentinel lymph node biopsy as a staging procedure in this particular neoplasm.

Downloads

Download data is not yet available.

References

Zembowicz A, Cohen JN, LeBoit PE. Pigmented Epithelioid Melanocytoma. In: Busam KJ, Gerami P, Scolyer RA, editor. Pathology of Melanocytic Tumors. Amsterdam: Elsevier; 2019. p.124–9.

Zembowicz A, Carney JA, Mihm CM Jr. Pigmented epithelioid melanocytoma, a low grade melanoma indistinguishable from animal type melanoma and epithelioid blue nevus. Am J Surg Pathol. 2004;28:31–40. doi: 10.1097/00000478-200401000-00002.

Carney JA, Ferreiro JA. The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma. Am J Surg Pathol. 1996;20:259–72.

Requena LM. Animal type melanoma: a report of a case with balloon-cell change and sentinel lymph node metastasis.. Am J Dermatopathol. 2001;23:341–6.

Ludgate MW, Fullen DR, Lee J, Rees R, Sabel MS, Wong SL, Johnson TM. Animal-type melanoma: a clinical and histopathological study of 22 cases from a single institution. Br J Dermatol 2010; 162: 129-36. doi: 10.1111/j.1365-2133.2009.09271.x.

Mandal RV, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW, et al. Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up. Am J Surg Pathol. 2009;33:1778-82. doi: 10.1097/PAS.0b013e3181b94f3c.

Zembowicz A, Knoepp SM, Bei T, Stergiopoulos S, Eng C, Mihm MC, et al. Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions. Am J Surg Pathol. 2007;31:1764–75. oi: 10.1097/PAS.0b013e318057faa7.

Lim C, Murali R, McCarthy SW, Krivanek J, Scolyer RA. Pigmented epithelioid melanocytoma: a recently described melanocytic tumour of low malignant potential. Pathology. 2010;42:284-6. doi: 10.3109/00313021003631213.

Cheng PS, Chuang SS, Kuo TT, Lai FJ. Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature. Dermatol Sinica. 2012;30:57-61. doi: 10.1016/j.dsi.2011.09.011.

Gavriilidis P, Michalopoulou I, Chatzikakidou K, Nikolaidou A. Pigmented epithelioid melanocytoma: a new concept encompassing animal-type melanoma and epithelioid blue nevus. BMJ Case Rep. 2013;2013:bcr-2013-008865. doi: 10.1136/bcr-2013-008865.