Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma with Brentuximab Vedotin: Report of Two Clinical Cases

  • Sandra Ferreira Serviço de Dermatologia, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal.
  • Iolanda Fernandes Serviço de Dermatologia, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal; Consulta Multidisciplinar de Linfomas Cutâneos e Mastocitoses, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal.
  • Renata Cabral Consulta Multidisciplinar de Linfomas Cutâneos e Mastocitoses, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal; Serviço de Hematologia Clínica, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal
  • Margarida Lima Consulta Multidisciplinar de Linfomas Cutâneos e Mastocitoses, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal; Serviço de Hematologia Clínica, Hospital de Santo António, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal
Keywords: Brentuximab Vedotin, Lymphoma, Primary Cutaneous Anaplastic Large Cell/drug therapy, Lymphoma, T-Cell, Cutaneous/drug therapy, Skin Neoplasms/drug therapy

Abstract

Brentuximab vedotin is approved by the Food and Drug Administration (FDA) and by the European Medicines Agency (EMA) for the treatment of adult patients with CD30-positive primary cutaneous T-cell lymphomas, refractory to at least one previous line of therapy. The authors report two clinical cases of primary cutaneous anaplastic large-cell lymphoma treated with brentuximab vedotin, with different clinical responses. Nevertheless, brentuximab vedotin may be a valid therapeutic alternative for the treatment of these pathologies.

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References

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Published
2021-04-05
How to Cite
Ferreira, S., Fernandes, I., Cabral, R., & Lima, M. (2021). Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma with Brentuximab Vedotin: Report of Two Clinical Cases. Journal of the Portuguese Society of Dermatology and Venereology, 79(1), 53-56. https://doi.org/10.29021/spdv.79.1.1277
Section
Case Reports