Treatment of BRAF-Mutated Metastatic Melanoma: Immunotherapy or Target Therapy?

  • Ana Sofia Rodrigues Faculdade de Medicina da Universidade de Coimbra, aluna do 6º ano do Mestrado Integrado em Medicina, Coimbra, Portugal http://orcid.org/0000-0003-0862-4072
  • Ana Brinca Serviço de Dermatologia do Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-7539-9912
Keywords: Immunotherapy, Melanoma/therapy, Molecular Targeted Therapy, Mutation, Protein Kinase Inhibitors/therapeutic use

Abstract

Metastatic melanoma has been associated with a poor prognosis, with overall survival rates at 5 years of 10%. Until 2011, the only treatments available for metastatic melanoma were chemotherapy and immunotherapy with interleukin-2. The more in-depth knowledge about the molecular biology of melanoma and the identification of BRAF mutations, which are the most frequently found, allowed us to find new therapeutic targets that came to modify the prognosis of these patients. Currently, the treatments available for metastatic melanoma with BRAF mutation are immunotherapy with immunological checkpoint inhibitors (anti-PD-1 to anti-CTLA-4) and targeted therapy with BRAF inhibitors and MEK inhibitors. However, the first-line therapy to be instituted in these patients remains unknown.

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Published
2021-06-25
How to Cite
Rodrigues, A. S., & Brinca, A. (2021). Treatment of BRAF-Mutated Metastatic Melanoma: Immunotherapy or Target Therapy?. Journal of the Portuguese Society of Dermatology and Venereology, 79(2), 103-111. https://doi.org/10.29021/spdv.79.2.1342
Section
Continuous Medica Education