LINFOMA DE CENTRO FOLICULAR CUTÂNEO PRIMÁRIO – UMA ENTIDADE A CONSIDERAR

Cristina Resende; Catarina Araújo; R. Santos; Celeste Brito

doi:10.29021/spdv.72.4.334

Cristina Resende Interno do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Braga, Portugal
Catarina Araújo Interno do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Braga, Portugal
R. Santos Interno do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Braga, Portugal
Celeste Brito Chefe de Serviço, Diretora do Serviço de Dermatologia e Venereologia/Consultant Chief, Head of Department of Dermatology and Venereology. Serviço de Dermatologia e Venereologia, Hospital de Braga, Braga, Portugal

DOI: https://doi.org/10.29021/spdv.72.4.334

Keywords: Lymphoma, follicular, Skin neoplasms

Abstract

Introduction: Follicular lymphoma is the most common B-cell lymphoma to occur as a primary tumor of skin.

Case report: The case of a 69-year-old caucasian female patient, with a 1 year history of a painless nodule, localized in the frontal region, which had been observed several times on urgency room. On examination, we observed a nontender nodule, 3x2 cm, localized in the frontal region with small papules at the periphery. Histopathologic examination of a biopsy from the nodule was suggestive of follicular lymphoma.

Immunophenotyping: CD20+, CD3-, CD5-, CD10+, Bcl2+ in rare cells. The patient was observed by Hematology/ Oncology and the staging was negative and a course of palliative chemotherapy with R-CHOP, followed by radiotherapy was given. During a follow-up of 6 months there wasn´t any evidence of recurrences.

Conclusion: This case report intends emphasize the relevance of educate the doctors for the diagnosis of this disease.

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References

Soon CW, Pincus LB, Ai WZ, McCalmont TH. Acneiform presentation of primary cutaneous follicle center lymphoma. J Am Acad Dermatol. 2011; 65(4):887-9.

Suárez AL, Querfeld C, Horwitz S, Pulitzer M, Moskowitz A, Myskowski PL. Primary cutaneous B-cell lymphomas: part II. Therapy and future directions. J Am Acad Dermatol. 2013; 69(3):343. e1-11.

Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C, Myskowski PL. Primary cutaneous B-cell lymphomas: part I. Clinical features, diagnosis, and classification. J Am Acad Dermatol. 2013; 69(3):329 e1-13.

Fernandez-Flores A, Smucler-Simonovich A, Escalante F, Manjon JA. The differential diagnosis between primary cutaneous large B-cell lymphoma and cutaneous follicular lymphoma: prognostic and therapeutic implications. Am J Dermatopathol. 2011; 33(8):819-26.

Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I, et al. Radiotherapy of primary cutaneous

follicle center lymphoma: case report and review of literature. Radiat Oncol. 2013; 8(1):147.

Lemeray J, Guillot B, Dereure O. A polycyclic annular erythematous plaque on the trunk: a quiz. Annular primary cutaneous follicle centre lymphoma. Acta Derm Venereol. 2012; 92(2):221-3.

PRIMARY CUTANEOUS FOLLICLE CENTER LYMPHOMA – A DIAGNOSIS TO CONSIDER

Abstract

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