PITYRIASIS LICHENOIDES - REPORT OF TWO CASES SHOWING THE WIDE SPECTRUM OF PRESENTATION OF THIS RARE DISEASE

  • Alexandre Sabino Sisnando Médico residente em Dermatologia/Resident of Dermatology, Fundação de Medicina Tropical Heitor Vieira Dourado (FMT-HVD)
  • Bárbara Agonio Médica residente em Dermatologia/Resident of Dermatology, Fundação de Medicina Tropical Heitor Vieira Dourado (FMT-HVD)
  • Laryssa Madeira Médica residente em Dermatologia/Resident of Dermatology, Fundação de Medicina Tropical Heitor Vieira Dourado (FMT-HVD)
  • Fabio Francesconi Dermatologista/Dermatologist, Mestre em doenças tropicais (pela FMT-HVD)/Specialist in tropical diseases, Preceptor da residência médica em dermatologia (FMT-HVD)/Tutor of residency in dermatology, Professor da disciplina de dermatologia/Professor of Dermatology, Faculdade de Medicina da Universidade Federal do Amazonas (FM-UFAM), Brasil
Keywords: Pityriasis lichenoides

Abstract

Pityriasis lichenoides is a rare skin disease of unknown etiology, whose spectrum of clinical presentation varies from an acute form, pityriasis lichenoides et varioliformis acuta (PLEVA) to a more insidious and recurrent one, pityriasis lichenoides chronica (PLC). PLEVA, or Mucha-Habermann disease, has an acute onset of papules on the trunk, buttocks and proximal extremities that rapidly progress to vesicles or form hemorrhagic crusts, and may leave depressed scars. PLC, by contrast, has small scaly papules, asymptomatic or pruritic, which can develop over days, on the same distribution. The lesions may continue appearing and disappearing over months, sometimes causing post-inflammatory hypopigmentation. The patient does not usually evolve from a clinical form to another, tending to spontaneous healing or the cure comes after treatment. It is believed that pityriasis lichenoides is a hypersensitivity reaction to various infectious agents and with self-limiting clonal proliferation of T cells, wherein the immune response to the clone leads to clinical and pathological manifestations. It has been detected T-cell receptor gamma gene rearrangement (TCR-gamma) by PCR. Pathological exam shows typical changes of each presentation. This paper presents two very representative cases of this uncommon disease, showing the main features of each form of pityriasis lichenoides. Both had resolution with the use of Doxycycline.

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References

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Published
2015-09-29
How to Cite
Sabino Sisnando, A., Agonio, B., Madeira, L., & Francesconi, F. (2015). PITYRIASIS LICHENOIDES - REPORT OF TWO CASES SHOWING THE WIDE SPECTRUM OF PRESENTATION OF THIS RARE DISEASE. Journal of the Portuguese Society of Dermatology and Venereology, 73(3), 383-387. https://doi.org/10.29021/spdv.73.3.463
Section
Case Reports