AMERICAN CUTANEOUS LEISHMANIASIS, WARTY ATYPICAL PRESENTATION, DIAGNOSED WITH MOLECULAR BIOLOGY TECHNIQUE
Abstract
American cutaneous leishmaniasis is an infectious, not contagious disease, caused by a protozoa from genus Leishmania and affects skin and mucosal tissue. The clinical symptoms is varied and it is related with the Leishmania species and the immune response of the host; Most common symptoms are single or multiples ulcerated lesions, however, we will present an atypical case of the disease. The patient presented mainly verrucous lesions in lower limbs, the polymerase chain reaction confirmed American cutaneous leishmaniasis diagnosis. After meglumine antimoniate treatment, the patient evolved with clinical improvement of the lesions, which supports the diagnosis. This case relevance is the need of knowledge of the disease atypical forms, in order to establish an early diagnosis and also an appropriate therapy.
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References
Brasil. Ministério da Saúde. Manual de Vigilancia da leishmaniose tegumentar americana. Brasília: Fundação Nacional de Saúde; 2013.
Mejía PA, Restrepo R, Toro AM. Leishmaniasis mucocutánea verrucosa: una manifestación inusual. Rev Asoc Col Dermatol.2008; 16:97-9.
Murback ND, Hans G, Nascimento RA, Nakazato KR, Dorval ME. American cutaneous leishmaniasis: clinical, epidemiological and laboratory studies conducted
at a university teaching hospital in Campo Grande, Mato Grosso do Sul, Brazil. An Bras Dermatol. 2011; 86:55-63.
Marfurt J, Nasereddin A, Niederwieser I, Jaffe CL, Beck HP, Felger I. Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment
length polymorphism analysis. J Clin Microbial. 2003;41:3147-53.
Guedes AC, de Carvalho ML, Melo MN. Leishmaniose tegumentar americana: apresentação pouco comum. An Bras Dermatol. 2008; 83:445-9.
Gontijo B, de Carvalho ML. Leishmaniose tegumentar americana. Rev Soc Brasil Med Trop. 2003; 36:71-80.
Guimarães LH, Machado PR, Lagoa EL, Morgan DJ,Schriefer A, Bacellar O, et al. Atypical manifestations of tegumentary leishmaniasis in a transmission area
of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg. 2009; 103: 712-5.
Lima EB, Porto C, Motta JC, Sampaio RN. Tratamento da leishmaniose tegumentar americana. An Bras Dermatol. 2007; 82:111-24.
De Grave W, Fernandes O, Campbell D, Bozza M, Lopes U. Use of molecular probes and PCR for detection and typing of Leishmania- a minireview. Mem Inst Oswaldo Cruz. 1994; 89: 463-9.
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