Sarcoidose

  • Sara Castelo Branco Interna de Medicina Interna/Resident, Internal Medicine, Unidade Funcional de Medicina 4, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Karin Luz Interna de Medicina Interna/Resident, Internal Medicine, Unidade Funcional de Medicina 4, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Cândida Fernandes Assistente Hospitalar Graduada de Dermatovenereologia/Graduated Consultant, Dermatology, Serviço de Dermatologia e Venereologia, Hospital de Curry Cabral, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Jorge Cardoso Chefe de Serviço de Dermatovenereologia/Consultant Chief, Dermatology, Hospital de Curry Cabral, Serviço de Dermatologia e Venereologia, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
Palavras-chave: Doenças da Pele, Granuloma, Sarcoidose

Resumo

A sarcoidose consiste numa doença inflamatória multissistémica, de etiologia desconhecida, que se caracteriza pela formação de granulomas não-caseosos nos órgãos envolvidos, predominantemente pulmões e gânglios intratorácicos. O envolvimento cutâneo ocorre em cerca de 25-35% dos casos, é habitualmente um achado precoce e constitui um local acessível e seguro para estudo histológico. As lesões cutâneas podem ter várias apresentações, incluindo pápulas, nódulos, placas e cicatrizes infiltradas. O diagnóstico baseia-se no reconhecimento das características clínicas, imagiológicas e histológicas e exclusão de outras doenças granulomatosas. O diagnóstico precoce e tratamento sistémico (quando necessário) poderão prevenir complicações futuras.

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Referências

Rybicki BA, Major M, Popovich J Jr, Maliarik MJ, Iannuzzi MC. Racial differences in sarcoidosis incidence: a 5-year

study in a health maintenance organization. Am J Epidemiol.

; 145: 234-41.

English JC, Patel PJ, Greer KE. Sarcoidosis. J Am Acad Dermatol. 2001; 44: 725-43.

Thomas KW, Hunninghake GW. Sarcoidosis. JAMA. 2003; 289: 3300-03.

Baughman RP, Lower EE, bu Bois RM. Sarcoidosis. Lancet 2003; 361: 1111-18.

Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med. 1997; 336: 1224-34.

Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, et al. Epidemiology of Sarcoidosis in Japan. Eur Respir

J. 2008; 31: 372.

Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, et al. A case control etiological study of

sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med. 2004; 170:1324-30.

Cox CE, Davis-Allen A, Judson MA. Sarcoidosis. Med Clin North Am. 2005; 89: 817-28.

Nunes H, Soler P, Valeyre D. Pulmonary sarcoidosis. Allergy. 2005; 60: 565-82.

Song Z, Marzilli L, Greenlee BM, Chen ES, Silver RF, Askin FB, et al. Mycobacterial catalase-peroxidase is a tissue

antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med. 2005;201:755-6.

Smith G, Brownell I, Sanchez M, Prystowsky S. Advances in the genetics of sarcoidosis. Clin Genet. 2008; 73: 401-12.

Sato H, Grutters JC, Pantelidis P, Mizzon AN, Ahmad T, Van Houte AJ, et al. HLA-DQB1*0201: a marker for good

prognosis in British and Dutch patients with sarcoidosis. Am J Respir Cell Mol Biol 2002; 27: 406-1.

Agostini C, Adami F, Semenzato G. New pathogenetic insights into the sarcoid granuloma. Curr Opin Rheumatol.

; 12:71-6.

Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007; 357: 2153-65.

Ma Y, Gal A, Koss MN. The pathology of pulmonary sarcoidosis: update. Semin Diagn Pathol. 2007; 24: 150-61.

Myers JL, Tazelaar HD. Challenges in pulmonary fibrosis: 6-Problematic granulomatous lung disease. Thorax

; 63: 78-84.

Elgart ML. Cutaneous sarcoidosis: definitions and types of lesions. Clin Dermatol. 1986; 4: 35-45.

Katta R. Cutaneous sarcoidosis: a dermatologic masquerader. Am Fam Physician. 2002; 65:1581–4.

Fernandez-Faith E, McDonnell J. Cutaneous sarcoidosis: differential diagnosis. Clin Dermatol. 2007; 25:276–87.

Yanardag, Pamuk ON, Karayel T. Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients.

Respir Med. 2003; 97: 978-82.

Leonard AL. A case of sarcoidosis mimicking rhinophyma. J Drugs Dermatol. 2003; 2: 333-4.

Mangas C, Fernández-Figueras MT, Fité E, Fernández-Chico N, Sàbat M, Ferrándiz C. Clinical spectrum and

histological analysis of 32 cases of specific cutaneous sarcoidosis. J Cutan Pathol. 2006; 33: 772-7.

Young RJ 3rd, Gilson RT, Yanase D, Elston DM. Cutaneous sarcoidosis. Int J Dermatol 2001; 40: 249-53.

Lodha S, Sanchez M, Prystowsky S. Sarcoidosis of the skin: a review for the pulmonologist. Chest. 2009; 136:

-96.

Albertini JG, Tyler W, Miller OF. Ulcerative sarcoidosis: case report and review of the literature. Arch Dermatol.

; 133: 215-21.

Lynch PJ, Sams WM Jr. Principles and practice of dermatology. New York:Churchill Livingstone;1996.

O'Regan A, Berman JS. Sarcoidosis. Ann Intern Med. 2012; 156: ITC5-1, ITC5-2, ITC5-3, ITC5-4, ITC5-5,

ITC5-6, ITC5-7, ITC5-8, ITC5-9, ITC5-10, ITC5-11, ITC5-12, ITC5-13, ITC5-14, ITC5-15; quiz ITC5-16.

Silverstein E, Pertschuk LP, Friedland J. Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc Natl Acad Sci USA. 1979; 76: 6646-8.

Studdy Pr, Bird R. Serum angiotensin converting enzyme in sarcoidosis- its value in present clinical practice. Ann Clin Biochem. 1989; 26: 13-8.

Baughman RP. Pulmonary sarcoidosis. Clin Chest Med. 2004; 25: 521-30.

Pietinalho A, Ohmichi M, Lofroos AB, Hiraga Y, Selroos O. The prognosis of sarcoidosis in Finland and Hokkaido,

Japan. A comparative five-year study of biopsy-proven cases. Sarcoidosis Vasc Diffuse Lung Dis. 2000;

:158-66.

Gronhagen-Riska C, Selroos O, Niemisto M. Angiotensin converting enzyme. V. Serum levels as monitors of disease activity in corticosteroid-treated sarcoidosis. Eur J Respire Dis. 1980; 61: 113-22.

Baughman RP, Ploysongsang Y, Roberts RD, Srivastava L. Effects of sarcoid and steroids on angiotensin-converting enzyme. Am Rev Respir Dis. 1983; 128: 631-3.

Deremee RA. Sarcoidosis. Mayo Clin Proc. 1995; 70: 177-81.

Scadding JG. Prognosis of intrathoracic sarcoidosis in England. BMJ. 1961; 4: 1165-72.

Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011; 183: 573-81.

Baughman RP, Shipley R, Eisentrout CE. Predictive value of gallium scan, angiotensin-converting enzyme level, and bronchoalveolar lavage in two-year follow-up of pulmonary sarcoidosis. Lung. 1987; 165: 371.

Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S. Radiologic manifestations in various organs. Radiographics. 2004; 24: 87-104.

Roberts SD, Mirowski GW, Wilkes D, Teague SD, Knox KS. Sarcoidosis. Part I: pulmonar manifestations. J Am Acad Dermatol. 2004; 51: 448-51.

Teirstein AS, Machac J, Almeida O, Lu P, Padilla ML, Iannuzzi MC. Results of 188 whole-body fluorodeoxyglucose

positron emission tomography scans in 137 patients with sarcoidosis. Chest. 2007; 132: 1949-53.

Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H Jr, Bresnitz EA, et al. Clinical characteristics of

patients in a case control study of sarcoidosis. Am J Respire Crit Care Med. 2001; 164: 1885-9.

Meyer KC, Raghu G, Baughman RP, Brown KK, Costabel U, du Bois RM, et al. An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease. Am J Respir Crit Care Med. 2012; 185: 1004-14.

de Boer S, Milne DG, Zeng I, Wilsher ML. Does CT scanning predict the likelihood of a positive transbronchial

biopsy in sarcoidosis? Thorax. 2009; 64: 436-9.

Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. Interstitial lung disease guideline:

the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zeland and the Irish

Thoracic Society. Thorax. 2008; 63 Suppl 5:v1-58.

Bjermer L, Thunell M, Rosenhall L, Sternberg N. Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease. Respir Med. 1991; 85: 229-34.

Haimovic A, Sanchez M, Judson MA, PrystowskyS. Sarcoidosis: a comprehensive review and update for the dermatologist: part II. Extracutaneous disease. J Am Acad Dermatol. 2012; 66: 719.e1-10.

Badgwell C, Rosen T. Cutaneous sarcoidosis therapy updated. J Am Acad Dermatol. 2007; 56: 69-83.

Müller-Quernheim J, Kienast K, Held M, Pfeifer S, Costabel U. Treatment of chronic sarcoidosis with an azathioprine/prednisolone regimen. Eur Respir J. 1999 14: 1117-22.

Hoitsma E, Faber CG, Drent M, Sharma OP. Neurosarcoidosis: a clinical dilemma. Lancet Neurol 2004; 3:

-407.

Doty JD, Mazur JE, Judson MA. Treatment of corticosteroid-resistant neurosarcoidosis with a short-course cyclophosphamide regimen. Chest. 2003; 124: 2023-6.

Doty JD, Mazur JE, Judson MA. Treatment of sarcoidosis with infliximab. Chest. 2005; 127:1064-71.

Milman N, Graudal N, Loft A, Mortensen J, Larsen J, Baslund B. Effect of the TNF-a inhibitor adalimumab in

patients with recalcitrant sarcoidosis: a prospective observational study using FDG-PET. Clin Respir J. 2012; 6:

-47.

Erckens RJ, Mostard RL, Wijnen PA, Schouten JS, Drent M. Adalimumab successful in sarcoidosis patients with refractory chronic non-infectious uveitis. Graefes Arch Clin Exp Ophthalmol. 2012; 250:713-20.

Bachelez H, Senet P, Cadranel J, Kaoukhov A, Dubertret L. The use of tetracyclines for the treatment of sarcoidosis. Arch Dermatol. 2001; 137: 69-73.

Wasfi Y, Rose C, Murphy J, Silveira L, Grutters J, Inoue Y, et al. A new tool to assess sarcoidosis severity. Chest.

; 129: 1234-45.

Publicado
2016-04-29
Como Citar
Castelo Branco, S., Luz, K., Fernandes, C., & Cardoso, J. (2016). Sarcoidose. Revista Da Sociedade Portuguesa De Dermatologia E Venereologia, 74(1), 25-31. https://doi.org/10.29021/spdv.74.1.512
Secção
Artigo de Revisão