Cutaneous Melanoma: Epidemiological Profile of Deaths in the State of São Paulo - Brazil between 2005 and 2014
Abstract
Introduction: Cutaneous melanoma (CM) is the least common skin cancer, but it accounts for the majority of deaths. This study aimed to evaluate the epidemiological profile of deaths due to CM in the State of São Paulo, as well as to evaluate the factors that may determine their occurrence by gender.
Methods: Data on CM mortality in the State of São Paulo, Brazil, between 2005 and 2014 were studied. Descriptive analyzes and univariate and multivariate logistic regression were performed to determine the probability of death in terms of gender according to demographic variables. Statistical analysis was based on OR calculation. In all analyzes, 95% confidence intervals were used and alpha = 5% level of significance was adopted.
Results: During the study period 4059 deaths due to CM were identified, representing 0.9% of the general mortality due to neoplasia. Of these, 56.7% were male and 92.4% were white. The mean age at death was 63.5 years (SD = 16.3). In the multivariate logistic regression, the absence of partner and the higher level of education showed to be discordant factors between genders.
Conclusion: This study evaluating the epidemiological profile of deaths due to CM, identified the predominance of the male gender, Caucasians and individuals with partners and a low level of education. There was a trend towards an increase in the number of deaths in the last 5 years of the study period. In addition, we observed differences in risk factors related to the gender.
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References
Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon
A, et al. The genetic evolution of melanoma from precursor
lesions. New Engl J Med. 2015; 373: 1926-36.
doi: 10.1056/NEJMoa1502583.
World Health Organization. Ultraviolet radiation and
the INTERSUN Programme [Internet]. [acesso em 27 abr
. Disponível em: http://www.who.int/uv/faq/skincancer/
en/index1.html.
Marks R. Epidemiology of melanoma. Clin Exp Dermatol.
; 25: 459-63.
Demográfico, IBGE Censo. "Fundação Seade (Sistema Estadual
de análise de Dados)” [Acesso em maio 2018] Disponível
Bonfá R, Bonamigo RR, Bonfá R, Duro KM, Furian RD, Zelmanowicz
AM. A precocidade diagnóstica do melanoma
cutâneo: uma observação no sul do Brasil. An Bras Dermatol.
; 86:215-21.
Whiteman DC, Green AC, Olsen CM. The growing burden
of invasive melanoma: projections of incidence rates
and numbers of new cases in six susceptible populations
through 2031. J Investig Dermatol. 2016 ; 136:1161-71.
doi: 10.1016/j.jid.2016.01.035.
Coory M, Baade P, Aitken J, Smithers M, McLeod GR, Ring
I. Trends for in situ and invasive melanoma in Queensland,
Australia, 1982–2002. Cancer Causes Control.
; 17:21-7.
Karimkhani C, Green AC, Nijsten T, Weinstock MA, Dellavalle
RP, Naghavi, M,et al. The global burden of melanoma:
results from the Global Burden of Disease Study
Br J Dermatol. 2017; 177: 134-40.
Instituto Nacional de Câncer José de Alencar Gomes da
Silva [homepage na internet]. Tipos de Câncer: Pele: Melanoma.
[acesso em 22/03/2018]. Disponível em: http://
www2.inca.gov.br
Ferreira FR, Nascimento LF. Mortality due to cutaneous
melanoma in south region of Brazil: a spatial approach.
An Bras Dermatol. 2016; 91:437-41.
Ferrari Júnior NM, Muller H, Ribeiro M, Maia M, Sanches
Júnior JA. Cutaneous melanoma: descriptive epidemiological
study. Sao Paulo Med J. 2008; 126:41-7.
Departamento de Informática do SUS – DATASUS. Estatísticas
Vitais. [Acesso em mar 2018] Disponível em:
Stata Corporation. Statistical software for professionals/
STATA [programa de computador]. Versão 9. Texas: College
Station; 2005.
Tuong, William, Lily S. Cheng, and April W. Armstrong.
"Melanoma: epidemiology, diagnosis, treatment, and outcomes."
Dermatol Clin. 2012; 30: 113-24.
Leiter U, Garbe C. Epidemiology of melanoma and
nonmelanoma skin cancer-the role of sunlight. Adv Exp
Med Biol. 2008; 624:89-103. doi: 10.1007/978-0-387-
-6_8.
Nikolaou V, Stratigos AJ. Emerging trends in the epidemiology
of melanoma. Br J Dermatol. 2014; 170: 11-9.
Pinto AC, Cavalcante ML, da Silva GV, de Brito FF, Oliveira
AM, Cleto NG. Melanoma maligno: estudo epidemiológico
dos casos diagnosticados em unidade de referência
em dermatologia em Bauru-sp de 2007 a 2014. Surg
Cosmetic Dermatol. 2015; 7: 104-7.
Martins-Costa GM, Bonamigo RR, Menegat AP, Costa LL,
Bonfá R, Grazziotin TC. Melanoma cutâneo primário:
confirmações e novidades. Rev AMRIGS. 2013; 57: 208-
Ferreira FR, Nascimento LF. Mortality due to cutaneous
melanoma in south region of Brazil: a spatial approach.
An Brasil Dermatol. 2016; 91:, 437-41.
Mikkilineni R, Weinstock MA. Epidemiology. In: Sober A,
Haluska F, editors. Skin cancer. London: BC Decker; 2001.
p. 1-15.
Cormier JN, Xing Y, Ding M, Lee JE, Mansfield PF, Gershenwald
JE, et al. Ethnic differences among patients with
cutaneous melanoma. Arch Intern Med. 2006; 166:1907-
doi: 10.1001/archinte.166.17.1907.
Hu S, Parmet Y, Allen G, Parker DF, Ma F, Rouhani P, et al.
Disparity in melanoma: a trend analysis of melanoma incidence
and stage at diagnosis among whites, Hispanics,
and blacks in Florida. Arch Dermatol. 2009;145:1369-
doi: 10.1001/archdermatol.2009.302.
Maia M, Basso M. Quem descobre o melanoma cutâneo?
An Bras Dermatol. 2006;81:244-8.
Mackie RM, Hole DJ. Incidence and thickness of primary
tumours and survival of patients with cutaneous malignant
melanoma in relation to socioeconomic status. BMJ.
;312:1125-8.
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