Lepromatous Leprosy: Report of a Histoid-Like Case
Histoid leprosy, described by Wade in 1963, represents an atypical variant of lepromatous leprosy, with its own clinical and pathological features. In the past, it was considered a marker of drug resistance and relapse. It presents as keloid-like plaque or nodular lesions. Optical microscopy shows few foamy macrophages and numerous alcohol-acid-resistant bacilli and an infiltrate composed predominantly of spindle cells, which can mimic fibrohistiocytic neoplasms. We report a case of lepromatous leprosy with lesions clinically compatible with the histoid variant in order to demonstrate and reinforce the clinical polymorphism of this type of Hansen’s disease and raise awareness for the need of an early diagnosis and treatment, therefore with the interruption of the transmission chain and reduction of the occurrence of irreversible leprosy-related disability.
Fischer M. Leprosy - an overview of clinical features, diagnosis, and treatment. J Dtsch Dermatol Ges. 2017; 15:801-27. doi: 10.1111/ddg.13301.
Araújo MG. Leprosy in Brazil. Rev Soc Bras Med Tropical. 2003; 36:373-82.
Wade HW. The histoid variety of lepromatous leprosy. IntJ Leprosy. 1963; 31:129-42.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Guia prático sobre a hanseníase [recurso eletrônico] / Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância das Doenças Transmissíveis. - Brasília : Ministério da Saúde, 2017. 68 p.
Desikan, KV, Iyer CG. Histoid variety of lepromatous leprosy: a histopathologic study. Int J Lepr. 1972; 40:149-56.
Bhutani LK, Bedi TR, Malhotra YK, Kandhari KC, Deo MG.. Histoid leprosy in North India. Int J Lepr Other Mycobact Dis. 1974; 42:174-81.
Price EW, Fitzherbert H. Histoid variety of lepromatous leprosy. Int J Lepr. 1966; 34:367-74.
Kontochristopoulos GL, Aroni K, Panteleos DN, Tosca AD. Immunohistochemistry in histoid leprosy. Int J Dermatol. 1995;34:777-81.
Cuevas-Santos J, Contreras F, McNutt NS. Multibacillary leprosy: lesions with macrophages positive for S100 protein and dendritic cells positive for Factor 13a. J Cutan Pathol. 1998; 25:530-7.
Sehgal V, Srivastava G. Status of histoid leprosy – a clinical, bacteriological, histopathological and immunological appraisal. J Dermatol. 1987; 14:38-42.
Gupta SK. Histoid leprosy: review of the literature. Int J Dermatol. 2015;54:1283-8. doi: 10.1111/ijd.12799.
Donath MY, Shoelson SE. Type 2 Diabetes as an inflammatory disease. Nat Rev Immun. 2011; 11:98-107. doi: 10.1038/nri2925.
Gross AM. Hanseníase no Brasil. Rev Soc Bras Med Trop. 2003; 36:373-82.
Sehgal VN, Srivastava G. Histoid leprosy. Int J Dermatol. 1985; 24:286-92.
Baslas RG, Gupta M, Arora SK, Mukhija RD, Misra RK. Palmar involvement in histoid leprosy. Indian J Lepr. 1992;64:193-5.
Manoharan R, Madhu R, Srinivasan MS. Histoid Hansen - A case report. J Indian Soc Tele Dermatol.
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