Melatonin and Atopic Dermatitis: New Insights in Pathophysiology and its Role in Sleep Disturbance

  • Ana Sofia Borges Serviço de Dermatovenerologia, Hospital Santo António dos Capuchos, Centro Hospitalar Lisboa Central, Lisboa, Portugal
  • A. Brasileiro Serviço de Dermatovenerologia, Hospital Santo António dos Capuchos, Centro Hospitalar Lisboa Central, Lisboa, Portugal
  • P. Mendes-Bastos Centro de Dermatologia, Hospital CUF Descobertas, Lisboa, Portugal
Keywords: Child, Dermatitis, Atopic, Melatonin /therapeutic use, Sleep Wake Disorders physiopathology


Sleep disturbance is common in children with atopic dermatitis, with a significant impact in their quality of life and negative effects on behavior and neurocognitive function. However, the pathophysiology of sleep disturbance in patients with atopic dermatitis is not well understood. It was thought to be consequence of pruritus and scratching, but nowadays we know to a consequence of multiple factors. Recent studies have suggested that melatonin could be involved, not only because of its primordial effect on sleep induction, but also its effects on immunomodulation and as anti-oxidant. In this review, the authors summarize the new insights about the sleep disturbances in children with atopic dermatitis, emphasizing the role of melatonin and its possible therapeutic implication.


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How to Cite
Borges, A. S., Brasileiro, A., & Mendes-Bastos, P. (2018). Melatonin and Atopic Dermatitis: New Insights in Pathophysiology and its Role in Sleep Disturbance. Journal of the Portuguese Society of Dermatology and Venereology, 76(4), 409-414.
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