Melatonina e Dermatite Atópica: Novos Conhecimentos sobre a Fisiopatologia e o seu Papel nas Perturbações do Sono

Ana Sofia Borges, A. Brasileiro, P. Mendes-Bastos

Resumo


As perturbações do sono são frequentes em crianças com dermatite atópica, com impacto negativo significativo na sua qualidade de vida e com consequências no seu comportamento e desempenho cognitivo. Porém, a fisiopatologia das perturbações do sono associadas à dermatite atópica é ainda pouco compreendida. Inicialmente consideradas consequência direta do prurido e do ato de escoriar associado durante o período noturno, hoje sabe-se que as perturbações do sono resultam de uma complexa interligação entre diversos fatores. Estudos recentes têm sugerido que a melatonina possa estar envolvida, não só pela função primordial de controlo do ciclo circadiano, mas também pelas características anti-inflamatória e antioxidante. Nesta revisão, os autores abordam os novos conhecimentos fisiopatológicos sobre os distúrbios do sono em crianças com dermatite atópica, focando o papel da melatonina e sua possível aplicação terapêutica.


Palavras-chave


Criança; Dermatite Atópica; Melatonina/uso terapêutico; Transtornos do Sono-Vigília/fisiopatologia

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DOI: http://dx.doi.org/10.29021/spdv.76.4.965

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