Fototerapia na População Pediátrica: Particularidades e Indicações

Ana Marcos-Pinto; Sónia Fernandes; Cristina Tapadinhas; Paulo Filipe

doi:10.29021/spdv.78.4.1255

Ana Marcos-Pinto Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal https://orcid.org/0000-0003-3477-0065
Sónia Fernandes Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal https://orcid.org/0000-0002-6936-2048
Cristina Tapadinhas Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
Paulo Filipe Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal; Unidade de Investigação em Dermatologia, IMM, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

DOI: https://doi.org/10.29021/spdv.78.4.1255

Keywords: Child, Phototherapy, Skin Diseases

Abstract

Nowadays, with the recent development of biological agents and other new drugs, some of which already approved in pediatric age, it is important to contextualize the role of phototherapy in dermatology. They have an excellent and well-recognized safety profile for decades, in addition to not requiring laboratory monitoring, which is an advantage, especially in the pediatric population. They have been successfully used in this age group in the treatment of several dermatological diseases. In this article, a review is carried out about the main particularities of the use of phototherapy in pediatric age, focusing on adverse effects, the main challenges, their indications and the individualized selection of different modalities, in order to improve the clinical practice of this therapy.

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References

Juarez MC, Grossberg AL. Phototherapy in the pediatric population. Dermatol Clin. 2020;38:91-108. doi: 10.1016/j.det.2019.08.012.

Magdaleno-Tapial J. Comparison of phototherapy in pediatric and adult patients. Actas Dermosifiliogr. 2020;111:41-6. doi: 10.1016/j.ad.2019.03.012.

Brasileiro A, Campos S, Rocha-Páris F, Fidalgo A, Apetato M. Systemic photochemotherapy in the treatment of adolescent psoriasis. Rev Soc Port Dermatol Venereol. 2016; 74:53-7. doi: 10.29021/spdv.74.1.515

Cruz MJ, Magina S, Boudrier T, Azevedo F. Psoriasis treatment in pediatric age – Part II: Phototherapy and systemic treatment. Rev Soc Port Dermatol Venereol. 2011; 69: 203-9. doi: 10.29021/spdv.69.2.606.

Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol. 2010; 62: 114-35. doi: 10.1016/j.jaad.2009.08.026.

Ersoy-Evans S, Altaykan A, Sahin S, Kölemen F. Phototherapy in childhood. Pediatr Dermatol. 2008; 25: 599-605. doi: 10.1111/j.1525-1470.2008.00773.x.

Pugashetti R, Koo J. Phototherapy in pediatric patients: choosing the appropriate treatment option. Semin Cutan Med Surg. 2010; 29: 115-20. doi: 10.1016/j.sder.2010.03.006.

Pavlovsky M, Baum S, Shpiro D, Pavlovsky L, Pavlotsky F. Narrow band UVB: is it effective and safe for paediatric psoriasis and atopic dermatitis? J Eur Acad Dermatol Venereol. 2011; 25:727-9. doi: 10.1111/j.1468-3083.2010.03832.x.

Tan E, Lim D, Rademaker M. Narrowband UVB phototherapy in children: A New Zealand experience. Australas J Dermatol. 2010; 51:268-73. doi: 10.1111/j.1440-0960.2010.00701.x.

Zamberk P, Velázquez D, Campos M, Hernanz JM, Lázaro P. Paediatric psoriasis – narrowband UVB treatment. J Eur Acad Dermatol Venereol. 2010; 24:415-9. doi: 10.1111/j.1468-3083.2009.03425.x.

Jain VK, Bansal A, Aggarwal K, Jain K. Enhanced response of childhood psoriasis to narrow-band UV-B phototherapy with preirradiation use of mineral oil. Pediatr Dermatol. 2008; 25:559-64. doi: 10.1111/j.1525-1470.2008.00729.x.

Jain VK, Aggarwal K, Jain K. Narrowband-UV–B phototherapy in childhood psoriasis. Int J Dermatol. 2007; 46:320-2. doi: 10.1111/j.1365-4632.2007.03148.x.

Jury CS, McHenry P, Burden AD, Lever R, Bilsland D. Narrow-band ultraviolet B (UVB) phototherapy in children. Clin Exp Dermatol. 2006; 31:196-9. doi: 10.1111/j.1365-2230.2006.02061.x.

Pasic A, Ceović R, Lipozencić J, Husar K, Susić Skerlev M, et al. Phototherapy in pediatric patients. Pediatr Dermatol. 2003; 20:71-7. doi: 10.1046/j.1525-1470.2003.03016.x.

Tay YK, Morelli JG, Weston WL. Experience with UVB Phototherapy in Children. Pediatr Dermatol. 1996; 13:406-9.

Al-Fouzan AS, Nanda A. UVB phototherapy in childhood psoriasis. Pediatr Dermatol. 1995; 12:66.

Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maître M, et al. Carcinogenic risks of Psoralen UV-A therapy and Narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol. 2012; 26 :22-31.

Pahlajani N, Katz BJ, Lozano AM, Murphy F, Gottlieb A. Comparison of the efficacy and safety of the 308 nm excimer laser for the treatment of localized psoriasis in adults and in children: a pilot study. Pediatr Dermatol. 2005; 22:161-5. doi: 10.1111/j.1525-1470.2005.22216.x.

Van Driessche F, Silverberg N. Current management of pediatric vitiligo. Paediatr Drugs. 2015; 17:303-13. doi: 10.1007/s40272-015-0135-3.

Tamesis ME, Morelli JG. Vitiligo treatment in childhood: a state of the art review. Pediatr Dermatol. 2010; 27:437-45. doi: 10.1111/j.1525-1470.2010.01159.x.

Yoshida A, Takagi A, Ikejima A, Takenaka H, Fukai T, Ikeda S. A retrospective study of 231 Japanese vitiligo patients with special reference to phototherapy. Acta Dermatovenerol Croat. 2014; 22:13-8.

Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with narrow-band UVB radiation therapy. J Am Acad Dermatol. 2000; 42:245-53.

Sen BB, Rifaioglu EN, Ekiz O, Sen T, Celik E, Dogramaci AC. Narrow-band ultraviolet B phototherapy in childhood. Cutan Ocul Toxicol. 2014; 33:189-91. doi: 10.3109/15569527.2013.832281.

Koh MJ, Mok ZR, Chong WS. Phototherapy for the treatment of vitiligo in Asian children. Pediatr Dermatol. 2015; 32:192-7.

Kanwar AJ, Dogra S. Narrow-band UVB for the treatment of generalized vitiligo in children. Clin Exp Dermatol. 2005;30:332-6. doi: 10.1111/pde.13431.

Brazzelli V, Prestinari F, Castello M, Bellani E, Roveda E, Barbagallo T,et al. Useful treatment of vitiligo in 10 children with UV-B narrowband (311 nm). Pediatr Dermatol. 2005;22:257-61. doi: 10.1111/j.1525-1470.2005.22319.x.

Percivalle S, Piccinno R, Caccialanza M, Forti S. Narrowband ultraviolet B phototherapy in childhood vitiligo: evaluation of results in 28 patients. Pediatr Dermatol. 2012; 29:160-5. doi: 10.1111/j.1525-1470.2011.01683.x.

Yazici S, Gunay B, Baskan EB, Aydoğan K, Saricaoğlu H, Tunali Ş. The efficacy of narrowband UVB treatment in pediatric vitiligo: a retrospective analysis of 26 cases. Turk J Med Sci. 2017;47:381-4. doi: 10.3906/sag-1512-59.

Park KK, Liao W, Murase JE. A review of monochromatic excimer light in vitiligo. BrJ Dermatol. 2012;167:468-78. doi: 10.1111/j.1365-2133.2012.11008.x.

Cho S, Zheng Z, Park YK, Roh MR. The 308-nm excimer laser: a promising device for the treatment of childhood vitiligo. Photodermatol Photoimmunol Photomed. 2011; 27:24-9. doi: 10.1111/j.1600-0781.2010.00558.x.

Dayal S, Pathak K, Sahu P. Narrowband UV-B phototherapy in childhood atopic dermatitis: efficacy and safety. An Bras Dermatol. 2017;92:801-806.

Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, et al. Guidelines of care for the management of atopic dermatitis: section3 Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol 2014;71:327-49. doi: 10.1016/j.jaad.2014.03.030.

Gambichler T, Breuckmann F, Boms S, Altmeyer P, Kreuter. A. Narrowband UVB phototherapy in skin conditions beyond psoriasis. J Am Acad Dermatol. 2005;52: 660-70.

Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018; 32:657-82. doi: 10.1111/jdv.14891.

Darne S, Leech SN, Taylor AE. Narrowband ultraviolet B phototherapy in children with moderate-to severe eczema: a comparative cohort study. Br J Dermatol. 2014;170:150-6.

Atherton DJ, Carabott F, Glover MT, Haw JL. The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents. Br J Dermatol. 1988;118:791-5. doi: 10.1111/j.1365-2133.1988.tb02597.x.

Sheehan MP, Atherton DJ, Norris P, Hawk JL. Oral psoralen photochemotherapy in severe childhood atopic eczema: an update. Br J Dermatol. 1993;129:431-6.

Nistico SP, Saraceno R, Capriotti E, Felice CD, Chimenti S. Efficacy of monochromatic excimer light (308 nm) in the treatment of atopic dermatitis in adults and children. Photomed Laser Surg. 2008;26:14-8. doi: 10.1089/pho.2007.2116.

Tan E, Lim D, Rademaker M. Narrowband UVB phototherapy in children: a New Zealand experience. Australas J Dermatol. 2010;51:268-73.

Mok ZR, Koh MJ, Chong WS. Is phototherapy useful in the treatment of atopic dermatitis in Asian children? A 5-year report from Singapore. Pediatr Dermatol. 2014;31:698-702.

Darwin E, Arora H, Hirt PA, Wikramanayake TC, Jimenez JJ. A review of monochromatic light devices for the treatment of alopecia areata. Lasers Med Sci. 2018; 33:435-44.

Al-Mutairi N. 308-nm excimer laser for the treatment of alopecia areata in children. Pediatr Dermatol. 2009; 26:547-550.

Tritrungtasna O, Jerasutus S, Suvanprakorn P. Treatment of alopecia areata with khellin and UVA. Int J Dermatol. 1993;32:690.

Fenniche S, Hammami H, Zaouak A. Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child. J Cosmet Laser Ther. 2018;20:156-8. doi: 10.1080/14764172.2017.1383617

Geller L, Antonov NK, Lauren CT, Morel KD, Garzon MC. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options. Pediatr Dermatol. 2015; 32:579-92. doi: 10.1111/pde.12581.

Laws PM, Shear NH, Pope E. Childhood mycosis fungoides: experience of 28 patients and response to phototherapy. Pediatr Dermatol. 2014; 31:459-64. doi: 10.1111/pde.12338.

Wu JH, Cohen BA, Sweren RJ. Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management. Pediatr Dermatol. 2020;37:18-28. doi: 10.1111/pde.14026.

Aranegui B, Jiménez-Reyes J. Morphea in Childhood: An Update. Actas Dermosifiliogr. 2018;109:312-22.

Marrani E, Foeldvari I, Lopez JA, Cimaz R, Simonini G. Comparing Ultraviolet Light A Photo(chemo)therapy With Methotrexate Protocol in Childhood Localized Scleroderma: Evidence From Systematic Review and Meta-Analysis Approach. Semin Arthritis Rheum. 2018;48:495-503. doi: 10.1016/j.semarthrit.2018.03.003.

Kreuter A, Hyun J, Stucker M, Sommer A, Altmeyer P, Gambichler T. A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma. J Am Acad Dermatol. 2006; 54: 440-7. doi: 10.1016/j.jaad.2005.11.1063.

Phototherapy in Pediatric Population: Particularities and Indications

Abstract

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