Cholinergic Urticaria Associated with Acquired Generalized Hypohidrosis: Two Case Reports and Review of the Literature

  • Cíntia Cruz Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Filipa Alexandra Matos Tavares Semedo Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal
  • Elza Maria Morgado Tomaz Immunoallergy Department, Centro Hospitalar de Setúbal, Setúbal, Portugal
  • Luís Miguel Nabais Borrego Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; CEDOC, NOVA Medical School, Nova University of Lisbon, Portugal; Comprehensive Health Research Centre (CHRC), NOVA Medical School, Nova University of Lisbon, Portugal
Keywords: Hypohidrosis/etiology, Urticaria/complications


Cholinergic urticaria is a relatively common condition defined by itching, redness and whealing induced by exercise and passive warming. In turn, acquired idiopathic generalized anhidrosis is a rare disorder of unknown pathogenesis, characterized by an impairment in total body sweating despite exposure to heat or exercise. We report two cases of this extremely rare association of cholinergic urticaria and acquired generalized hypohidrosis, and briefly review current knowledge with regard to classification, ethiopathogenesis and therapeutic options.


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How to Cite
Cruz, C., Matos Tavares Semedo, F. A., Morgado Tomaz, E. M., & Nabais Borrego, L. M. (2021). Cholinergic Urticaria Associated with Acquired Generalized Hypohidrosis: Two Case Reports and Review of the Literature. Journal of the Portuguese Society of Dermatology and Venereology, 79(1), 57-60.
Case Reports