Urticária Colinérgica Associada a Hipohidrose Generalizada Adquirida: Dois Casos Clínicos e Revisão da Literatura

  • Cíntia Cruz Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal https://orcid.org/0000-0001-6749-3450
  • Filipa Alexandra Matos Tavares Semedo Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal https://orcid.org/0000-0003-2762-9354
  • Elza Maria Morgado Tomaz Immunoallergy Department, Centro Hospitalar de Setúbal, Setúbal, Portugal https://orcid.org/0000-0001-8880-9629
  • Luís Miguel Nabais Borrego Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; CEDOC, NOVA Medical School, Nova University of Lisbon, Portugal; Comprehensive Health Research Centre (CHRC), NOVA Medical School, Nova University of Lisbon, Portugal https://orcid.org/0000-0003-4708-438X
Palavras-chave: Hipohidrose/etiologia, Urticária/complicações

Resumo

A urticária colinérgica é uma patologia relativamente comum definida por máculo-pápulas eritematosas e pruriginosas induzidas por aumento da temperatura corporal, passivo ou induzido por exercício físico. Pelo contrário, a anidrose generalizada idiopática adquirida é uma doença rara de patogénese desconhecida, caraterizada por um comprometimento da capacidade de sudação, apesar da exposição a calor ou exercício. Descrevem-se dois casos desta associação extremamente rara de urticária colinérgica e hipohidrose generalizada adquirida, e procede-se a uma breve revisão do conhecimento atual no que respeita à classificação, etiopatogenia e opções terapêuticas.

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Referências

Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018; 73:1393-414.

Hatakeyama M, Fukunaga A, Washio K, Ogura K, Yamada Y, Horikawa T, et al. Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists. J Dermatol Sci. 2016; 82:137-9.

Fukunaga A, Washio K, Hatakeyama M, Oda Y, Ogura K, Horikawa T, et al. Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. Clin Auton Res. 2018; 28:103-13.

Fukunaga A, Hatakeyama M, Tsujimoto M, Oda Y, Washio K, Nishigori C. Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. Br J Dermatol. 2015; 172:537-8.

Munetsugu T, Fujimoto T, Oshima Y, Sano K, Murota H, Satoh T, et al. Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan. J Dermatol. 2017; 44:394-400.

Fukunaga A, Bito T, Tsuru K, Oohashi A, Yu X, Ichihashi M, et al. Responsiveness to autologous sweat and serum in cholinergic urticaria classifies its clinical subtypes. J Allergy Clin Immunol. 2005; 116:397-402.

Washio K, Fukunaga A, Onodera M, Hatakeyama M, Taguchi K, Ogura K, et al. Clinical characteristics in cholinergic urticaria with palpebral angioedema: report of 15 cases. J Dermatol Sci. 2017; 85:135-7.

Vadas P, Sinilaite A, Chaim M. Cholinergic urticaria with anaphylaxis: an underrecognized clinical entity. J Allergy Clin Immunol Pract. 2016; 4:284-91.

Satoh T. Clinical analysis and management of acquired idiopathic generalized anhidrosis. Curr Probl Dermatol. 2016; 51:75-9.

Watanabe T, Iwase S, Saito K, Nagatani T, Yoshida J. Altered sympathetic thermoregulation in patients with hypothalamic dysfunction following resection of suprasellar tumors. Auton Neurosci. 2004; 112: 80-7.

Sawada Y, Nakamura M, Bito T, Fukamachi S, Kabashima R, Sugita K, et al. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. J Invest Dermatol. 2010; 130:2683-6.

Asahina M, Sano K, Fujinuma Y, Kuwabara S. Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. Intern Med. 2013; 52: 2733-7.

Kobayashi H, Aiba S, Yamagishi T, Tanita M, Hara M, Saito H, et al. Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. Dermatology. 2002; 204:173-8.

Magerl M, Altrichter S, Borzova E, Gimenez-Arnau A, Grattan CEH, Lawlor F, et al. The definition, diagnostic testing, and management of chronic inducible urticarias – The EAACI/GA2LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 2016; 71(6):780-802.

Koch K, Weller K, Werner A, Maurer M, Altrichter S. Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. J Allergy Clin Immunol. 2016; 138:1483-5.e9.

Tsunemi Y, Ihn H, Saeki H, Tamaki K. Cholinergic urticaria successfully treated with scopolamine butylbromide. Int J Dermatol. 2003; 42:850.

Feinberg J, Toner C. Successful treatment of disabling cholinergic urticaria. Mil Med. 2008; 173:217-20.

Sabroe R. Failure of omalizumab in cholinergic urticaria. Clin Exp Dermatol. 2010; 35:e127-9.

Rho N. Cholinergic urticaria and hypohidrosis: a clinical reappraisal. Dermatology. 2006; 213:357-8.

Ohshima Y, Yanagishita T, Ito K, Tamada Y, Nishimura N, Inukai Y, et al. Treatment of patients with acquired idiopathic generalized anhidrosis. Br J Dermatol. 2013; 168:430-2.

Kozaru T, Fukunaga A, Taguchi K, Ogura K, Nagano T, Oka M, et al. Rapid desensitization with autologous sweat in cholinergic urticaria. Allergol Int. 2011; 60:277-81.

Nakamizo S, Egawa G, Miyachi Y, Kabashima K. Cholinergic urticaria: pathogenesis-based categorization and its treatment options. J Eur Acad Dermatol Venereol. 2012; 26:114-6.

Minowa T, Sumikawa Y, Kan Y, Kamiya T, Uhara H. Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis. Dermatol Ther. 2020; 33:e13647.

Publicado
2021-04-05
Como Citar
Cruz, C., Matos Tavares Semedo, F. A., Morgado Tomaz, E. M., & Nabais Borrego, L. M. (2021). Urticária Colinérgica Associada a Hipohidrose Generalizada Adquirida: Dois Casos Clínicos e Revisão da Literatura. Revista Da Sociedade Portuguesa De Dermatologia E Venereologia, 79(1), 57-60. https://doi.org/10.29021/spdv.79.1.1320
Secção
Casos Clínicos