Cholinergic Urticaria Associated with Acquired Generalized Hypohidrosis: Two Case Reports and Review of the Literature

Cíntia Cruz; Filipa Alexandra Matos Tavares Semedo; Elza Maria Morgado Tomaz; Luís Miguel Nabais Borrego

doi:10.29021/spdv.79.1.1320

Cíntia Cruz Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal https://orcid.org/0000-0001-6749-3450
Filipa Alexandra Matos Tavares Semedo Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal https://orcid.org/0000-0003-2762-9354
Elza Maria Morgado Tomaz Immunoallergy Department, Centro Hospitalar de Setúbal, Setúbal, Portugal https://orcid.org/0000-0001-8880-9629
Luís Miguel Nabais Borrego Immunoallergy Department, Hospital da Luz Lisboa, Lisbon, Portugal; CEDOC, NOVA Medical School, Nova University of Lisbon, Portugal; Comprehensive Health Research Centre (CHRC), NOVA Medical School, Nova University of Lisbon, Portugal https://orcid.org/0000-0003-4708-438X

DOI: https://doi.org/10.29021/spdv.79.1.1320

Keywords: Hypohidrosis/etiology, Urticaria/complications

Abstract

Cholinergic urticaria is a relatively common condition defined by itching, redness and whealing induced by exercise and passive warming. In turn, acquired idiopathic generalized anhidrosis is a rare disorder of unknown pathogenesis, characterized by an impairment in total body sweating despite exposure to heat or exercise. We report two cases of this extremely rare association of cholinergic urticaria and acquired generalized hypohidrosis, and briefly review current knowledge with regard to classification, ethiopathogenesis and therapeutic options.

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