Topical Photodynamic Therapy as a Treatment Option for Periocular Bowen's Disease: A Case Report
Cutaneous squamous cell carcinoma in situ of the eyelid and periorbital skin malignancies is common and its management is demanding. Surgical excision is considered the first-line treatment, but these techniques have limitations. Topical photodynamic therapy is currently approved for the treatment of squamous cell carcinoma in situ in other areas, but the reports of its use in this sensitive anatomic location area are scarce. Herein we report the case of a 61-year-old-man with extensive periocular Bowen disease that was treated successfully with photodynamic therapy. Photodynamic therapy may be an option as neoadjuvant or curative therapy in selected cases, especially in sensitive anatomic locations where surgery might lead to distortion of the structures or where techniques as micrographically controlled surgery are not available.
Stratigos AJ, Garbe C, Dessinioti C, et al. European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment. Eur J Cancer. 2020;128:83-102. doi:10.1016/j.ejca.2020.01.008
Nägeli MC, Ramelyte E, Dummer R. Cutaneous squamous cell carcinomas on special locations: perioral, periocular and genital area. J Eur Acad Dermatology Venereol. 2019;33(S8):21-24. doi:10.1111/jdv.15901
Morton CA, Szeimies R ‐M., Basset‐Seguin N, et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen’s disease and basal cell carcinomas. J Eur Acad Dermatology Venereol. 2019;33(12):2225-2238. doi:10.1111/jdv.16017
Attili SK, Ibbotson SH, Fleming C. Role of non-surgical therapies in the management of periocular basal cell carcinoma and squamous intra-epidermal carcinoma: A case series and review of the literature. Photodermatol Photoimmunol Photomed. 2012;28(2):68-79. doi:10.1111/j.1600-0781.2011.00640.x
Casie Chetty N, Hemmant B, Skellett AM. Periocular photodynamic therapy for squamous intra-epidermal carcinoma. J Dermatolog Treat. 2014;25(6):516-518. doi:10.3109/09546634.2013.849793
Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles in this journal are Open Access under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).