DERMATOSE BOLHOSA IGA LINEAR EM DOENTE COM COLITE ULCEROSA – UMA ASSOCIAÇÃO RARA MAS ESTABELECIDA

António Fernandes Massa; Catarina Moreira; Cármen Lisboa; Paulo Santos; Joana Pardal; Filomena Azevedo

doi:10.29021/spdv.72.4.331

António Fernandes Massa Interno do Internato de Dermatovenereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia, Centro Hospitalar V. N. Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal
Catarina Moreira Interna do Internato Complementar de Dermatovenerelogia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, C.H. de S. João EPE, Porto, Portugal; Faculdade de Medicina, Universidade do Porto/Medical School, O’Porto University, Portugal
Cármen Lisboa Assistente Hospitalar Graduado/Graduated Consultant, Serviço de Dermatologia e Venereologia, C.H. de S. João EPE, Porto, Portugal; Faculdade de Medicina, Universidade do Porto/Medical School, O’Porto University, Portugal
Paulo Santos Assistente Hospitalar Graduado/Graduated Consultant, Serviço de Dermatologia e Venereologia, C.H. de S. João EPE, Porto, Portugal
Joana Pardal Interna do Internato Complementar de Anatomia Patológica/Resident, Pathology, Serviço de Anatomia Patológica, C.H. de S. João EPE Porto, Portugal
Filomena Azevedo Chefe de Serviço e Directora de Serviço/Consultant Chief and Head, Serviço de Dermatologia e Venereologia, C.H. de S. João EPE, Porto, Portugal

DOI: https://doi.org/10.29021/spdv.72.4.331

Keywords: Linear IgA bullous dermatosis, Skin diseases, Vesiculobullous, Ulcerative colitis, Inflammatory bowel disease

Abstract

The association of linear IgA bullous dermatosis (LABD) with ulcerative colitis (UC) is defined, although the etiology of this association is still unclear. We report the case of a 41 year-old female patient with UC diagnosed 6 years ago with a crisis 2 months ago, referred for pruriginous and tense bullae with 1 month of evolution. Her past medical history was relevant for gestational diabetes, reactive depression and hypertension. She was medicated with mesalazine for 1,5 years, bisoprolol, mexazolam and drospirenone/ethinyl estradiol. Cutaneous biopsy showed a bulla on the dermoepidermal junction (DEJ) and a polymorphous inflammatory dermal infiltrate. Linear immunoreactivity for IgA on the DEJ confirmed the diagnosis of LABD. Prednisolone and dapsone were initiated with good clinical response, maintained after six months of follow-up. The aetiology of this association remains unknown, being hypothesised cross-reactivity of IgA idiotype from UC with the dermoepidermal antigens. Mesalazine imputability cannot be surely ruledout as the cause of LABD in this patient.

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LINEAR IMMUNOGLOBULIN A BULLOUS DERMATOSIS IN A PATIENT WITH ULCERATIVE COLITIS – A RARE BUT ESTABLISHED ASSOCIATION

Abstract

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