PRIMARY CUTANEOUS INFECTION WITH SCEDOSPORIUM APIOSPERMUM IN AN IMMUNOCOMPROMISED PATIENT SUCCESSFULLY TREATED WITH VORICONAZOLE

  • Ana Isabel Gouveia Interna da Formação Específica em Dermatovenereologia/Resident, Dermatology and Venereology Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa
  • Leonor Lopes Interna da Formação Específica em Dermatovenereologia/Resident, Dermatology and Venereology Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa
  • M. Gomes Serviço de Medicina I B, Hospital de Santa Maria, Lisboa
  • Luís Soares de Almeida Professor Doutor do Serviço de Dermatologia e Venereologia/Professor of Dermatology and Venereology, Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa Serviço de Dermatovenereologia, Centro Hospitalar de Lisboa Norte – Hospital de Santa Maria, Lisboa, Portugal
  • Paulo Filipe Professor Doutor do Serviço de Dermatologia e Venereologia/Professor of Dermatology and Venereology, Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa Serviço de Dermatovenereologia, Centro Hospitalar de Lisboa Norte – Hospital de Santa Maria, Lisboa, Portugal
Keywords: Antifungal agents, Opportunistic infections, Scedosporium skin diseases, Infectious

Abstract

During the last decades, the incidence of opportunistic fungal infections has been increasing, namely in the context of immunosuppression. The Scedosporium apiospermum is a ubiquitous filamentous fungus in soil, decaying vegetation, sewers and polluted waters. Can cause infections in immunocompetent patients after trauma and severe and potentially fatal infections in immunocompromised patients. The authors describe a case of an infection by S. apiospermum on the dorsum of the left foot of a patient under prolonged systemic corticosteroid therapy combined with methotrexate due to the diagnosis of giant cell arteritis. Treatment of these infections can be a challenge due to the inherent resistance to many of the available systemic antifungal agents, including amphotericin B. In the case described, therapy with voriconazole was performed, with complete resolution of the lesions.

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References

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How to Cite
Gouveia, A. I., Lopes, L., Gomes, M., Soares de Almeida, L., & Filipe, P. (1). PRIMARY CUTANEOUS INFECTION WITH SCEDOSPORIUM APIOSPERMUM IN AN IMMUNOCOMPROMISED PATIENT SUCCESSFULLY TREATED WITH VORICONAZOLE. Journal of the Portuguese Society of Dermatology and Venereology, 72(4), 579-582. https://doi.org/10.29021/spdv.72.4.332
Section
Case Reports