BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY

  • Leonor Ramos Interna da Formação Específica em Dermatovenereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
  • Pedro Simões Interno de Ortopedia e Traumatologia/Resident, Orthopaedics and Traumatology Department, Serviço de Ortopedia e Traumatologia do Centro Hospitalar e Universitário de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
  • Miguel Gouveia Interno da Formação Específica em Dermatovenereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
  • Neide Pereira Assistente de Dermatovenereologia /Consultant of Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
  • José Carlos Cardoso Assistente de Dermatovenereologia /Consultant of Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
  • Américo Figueiredo Director do Serviço de Dermatologia e Venereologia do Centro Hospitalar Universitário de Coimbra/Professor of Dermatology and Venereology and Head of the Dermatology Department, Faculdade de Medicina da Universidade de Coimbra, Centro Hospitalar Universitário de Coimbra/Coimbra University, Portugal
Keywords: Breast neoplasms, Hemangiosarcoma, Radiotherapy

Abstract

Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.

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References

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How to Cite
Ramos, L., Simões, P., Gouveia, M., Pereira, N., Cardoso, J. C., & Figueiredo, A. (1). BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY. Journal of the Portuguese Society of Dermatology and Venereology, 72(4), 593-597. https://doi.org/10.29021/spdv.72.4.335
Section
Case Reports