PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY

  • Catarina Araújo Interna do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Sete Fontes – São Victor, Braga, Portugal
  • Cristina Resende Interna do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Sete Fontes – São Victor, Braga, Portugal
  • Ana Paula Vieira Assistente Hospitalar Graduado de Dermatologia e Venereologia/Consultant, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Sete Fontes – São Victor, Braga, Portugal
  • José Carlos Fernandes Assistente Hospitalar Graduado de Dermatologia e Venereologia/Consultant, Dermatology and Venereology, Serviço de Dermatologia e Venereologia, Hospital de Braga, Sete Fontes – São Victor, Braga, Portugal
  • Celeste Brito Chefe de Serviço, Directora do Serviço de Dermatologia e Venereologia/Consultant Chief, Head of Department of Dermatology and Venereology Serviço de Dermatologia e Venereologia, Hospital de Braga, Sete Fontes – São Victor, Braga, Portugal
Keywords: Antibodies, monoclonal, Down syndrome, Psoriasis

Abstract

Introduction: Psoriasis occurs in up to 8% of patients with Down syndrome and, although poorly characterized, appears to be correlated with immune imbalance in cells Th1 and biochemical changes of cyclic nucleotides.

Case report: Female patient, 38 years old, with Down syndrome and psoriasis (initial PASI 30) since 18 years. Initially treated with cyclosporine and methotrexate and subsequently with etanercept, adalimumab and ustecinumab because of progressive loss of response (current PASI 10).

Conclusion: We describe this case for the poor response to treatment including various biological agents. Potential poor adherence to therapy and immune dysfunction may limit the therapeutic options.

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References

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Published
2015-06-06
How to Cite
Araújo, C., Resende, C., Vieira, A. P., Fernandes, J. C., & Brito, C. (2015). PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY. Journal of the Portuguese Society of Dermatology and Venereology, 73(1), 147-150. https://doi.org/10.29021/spdv.73.1.357
Section
Case Reports

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