Major Multiform Erythema with Sertraline

  • Sandrina Carvalho Interna de Dermatologia/Resident, Dermatology and Venereology, Centro Hospitalar do Porto- HSA, Porto, Portugal
  • Madalena Sanches Assistente Hospitalar de Dermatologia/Consultant, Dermatology and Venereology, Centro Hospitalar do Porto- HSA, Porto, Portugal
  • Glória Cunha Velho Assistente Hospitalar de Dermatologia/Consultant, Dermatology and Venereology, Centro Hospitalar do Porto- HSA, Porto, Portugal
  • Rosário Alves Assistente Hospitalar de Dermatologia/Consultant, Dermatology and Venereology, Centro Hospitalar do Porto- HSA, Porto, Portugal
  • Manuela Selores Chefe de Serviço e Diretora do Serviço de Dermatologia/Consultant Chief and Head of Dermatology and Venereology Department, Centro Hospitalar do Porto- HSA, Porto, Portugal
Keywords: Erythema Multiforme/chemically induced, Sertraline/adverse effects

Abstract

Sertraline is frequently used for treatment of depressive and anxiety syndromes. Side effects are usually transient, and dose-dependent. We describe the case of a 76-year-old woman with depressive syndrome, and a history of recent introduction of sertraline who came to the emergency department with fever, and a cutaneous rash with two days of evolution. On examination, we noticed erythematous target papules, and exulcerations of oral mucosa. A skin biopsy was performed for histopathological examination with diagnosis of major multiforme erythema associated with sertraline. The patient stopped the drug in question, and initiated oral prednisolone with good resolution. Although uncommon, there are reported cases of severe skin reaction consequent to sertraline.

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Published
2015-09-29
How to Cite
Carvalho, S., Sanches, M., Cunha Velho, G., Alves, R., & Selores, M. (2015). Major Multiform Erythema with Sertraline. Journal of the Portuguese Society of Dermatology and Venereology, 73(3), 393-396. https://doi.org/10.29021/spdv.73.3.465
Section
Case Reports

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