Cutaneous Lymphoid Infiltrates Simulating Cutaneous Lymphoma

  • Ana Isabel Teixeira Interna do Internato Complementar de Dermatovenereologia/Resident of Dermatology, Serviço de Dermatovenereologia, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
  • Ana Isabel Gouveia Interna do Internato Complementar de Dermatovenereologia/Resident of Dermatology, Serviço de Dermatovenereologia, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
  • Susana Brás Interna do Internato Complementar de Dermatovenereologia/Resident of Dermatology, Serviço de Dermatovenereologia, Centro Hospitalar Lisboa Central, Lisboa, Portugal
  • Luís Miguel Soares de Almeida Assistente Hospitalar Graduado de Dermatovenereologia/Graduated Consultant of Dermatology; Professor associado de Dermatologia/Associted Professor of Dermatology, Unidade de Investigação em Dermatologia, IMM Lisboa, Serviço de Dermatovenereologia, Centro Hospitalar Lisboa Norte, Portugal
Keywords: Lymphoma, Pseudolymphoma, Skin Neoplasms

Abstract

Cutaneous pseudolymphoma refers to a heterogenous group of dermatosis which simulates cutaneous malignant lymphomas clinically and/or histopathologically. There are no diagnostic criteria to differentiate reactive from neoplastic infiltrates. Cutaneous pseudolymphoma can be divided into T- and B-cell variants depending on the predominant cell type in the infiltrate or classified according to the specific malignant lymphoma they simulate. This paper attempts to discuss the clinical and histological clues that are most relevant to the discrimination of lymphoma simulators from the true cutaneous lymphoma.

Downloads

Download data is not yet available.

References

Cerroni L. Skin Lymphoma: The illustrated Guide. 4th ed. Oxford:John Wiley & Sons; 2014.

Ploysangam T, Breneman DL, Mutasim DF. Cutaneous pseudolymphomas. J Am Acad Dermatol. 1998; 38:877-95; quiz 896-7.

Heller P, Wieczorek R, Waldo E, Meola T, Buchness MR, Soter NA, et al. Chronic actinic dermatitis: an immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. Am J Dermatopathol 1994; 16:510-6.

Norris PG, Morris J, Smith NP, Chu AC, Hawk JL. Chronic actinic dermatitis: an immunohistologic and photobiologic

study. J Am Acad Dermatol 1989; 21:966-71.

Pacheco D, Fraga A, Travassos AR, Antunes J, Freitas J, Soares de Almeida L, et al. Actinic reticuloid imitating

Sézary syndrome. Acta Dermatovenerol Alp Pannonica Adriat. 2012; 21:55-7.

Knackstedt TJ, Zug KA. T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.

Contact Dermatitis. 2015; 72:65-74.

Gomez Orbaneja J, Iglesias Diez L, Sanchez Lozano JL, Conde Salazar L. Lymphomatoid contact dermatitis. Contact

Dermatitis. 1976; 2:139-43.

Martinez-Moran C, Sanz-Munoz C, Morales-Callaghan AM, Garrido-Rios AA, Torrero V, Miranda-Romero A.

Lymphomatoid contact dermatitis. Contact Dermatitis 2009; 60:53-5.

Kossard S. Unilesional mycosis fungoides or lymphomatoid keratosis? Arch Dermatol 1997; 133:1312-3.

Choi MJ, Kim HS, Kim HO, Song KY, Park YM. A case of lymphomatoid keratosis. Ann Dermatol. 2010; 22:219-22.

Fink-Puches R, Wolf P, Kerl H, Cerroni L. Lichen aureus. Clinicopathologic features, natural history, and relationship

to mycosis fungoides. Arch Dermatol 2008; 144:1169-73.

Citarella L, Massone C, Kerl H, Cerroni L. Lichen sclerosus with histopathologic features simulating early mycosis

fungoides. Am J Dermatopathol 2003; 25:463-5.

Cerroni L1, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H. Solitary skin lesions with histopathologic

features of early mycosis fungoides. Am J Dermatopathol. 1999; 21:518-24.

Beltraminelli H1, Leinweber B, Kerl H, Cerroni L. Primary cutaneous CD4+ small-/medium-sized pleomorphic

T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance?

A study of 136 cases. Am J Dermatopathol. 2009;31:317-22.

Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas.

Blood. 2005; 105:3768-85.

El-Shabrawi-Caelen L, Kerl H, Cerroni L. Lymphomatoid papulosis. Reappraisal of clinicopathologic presentation

and classification into subtypes A, B, and C. Arch Dermatol. 2004; 140:441.

Werner B, Massone C, Kerl H, Cerroni L. Large CD30-positive cells in benign, atypical lymphoid infiltrates of

the skin. J Cutan Pathol. 2008; 35:1100-7.

Hwong H, Jones D, Prieto VG, Schulz C, Duvic M. Persistent atypical lymphocytic hyperplasia following tick bite

in a child: report of a case and review of the literature. Pediatr Dermatol.2001; 18:481.

Gallardo F, Barranco C, Toll A, Pujol RM. CD30 antigen expression in cutaneous inflammatory infiltrates of scabies:

a dynamic immunophenotypic pattern that should be distinguished from lymphomatoid papulosis. J Cutan Pathol. 2002; 29:368.

Leinweber B, Kerl H, Cerroni L. Histopathologic features of cutaneous herpes virus infections (herpes simplex, herpes

varicella/zoster). A broad spectrum of presentations with common pseudolymphomatous aspects. Am J Surg Pathol. 2006; 30:50-5

Moreno-Ramírez D, García-Escudero A, Ríos-Martín JJ, Herrera-Saval A, Camacho F. Cutaneous pseudolymphoma in association with molluscum contagiosum in an elderly patient. J Cutan Pathol. 2003; 30:473-5.

Del Boz González J, Sanz A, Martín T, Samaniego E, Martínez S, Crespo V. Cutaneous pseudolymphoma associated

with molluscum contagiosum: a case report. Int J Dermatol. 2008; 47:502-4.

Massone C, Kodama K, Salmhofer W, Abe R, Shimizu H, Parodi A, et al. Lupus erythematosus panniculitis (lupus

profundus): clinical, histopathological, and molecular analysis of nine cases. J Cutan Pathol 2005; 32:396-404.

Bosisio F, Boi S, Caputo V, Chiarelli C, Oliver F, Ricci R, et al. Lobular panniculitic infiltrates with overlapping histopathologic features of lupus panniculitis (lupus profundus) and subcutaneous T-cell lymphoma: A conceptual and practical dilemma. Am J Surg Pathol. 2015;39:206-11.

Sarantopoulos GP, Palla B, Said J, Kinney MC, Swerdlow SM, Willemze R, et al. Mimics of cutaneous lymphoma:

report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am

J Clin Pathol. 2013; 139:536-51.

Breza TS Jr, Zheng P, Porcu P, Magro CM. Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine

therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response. J

Cutan Pathol. 2006; 33:522-8.

Crowson AN, Magro CM. Antidepressant therapy: a possible cause of atypical cutaneous lymphoid hyperplasia.

Arch Dermatol. 1995; 131:925-9.

Arps DP1, Chen S, Fullen DR, Hristov AC. Selected inflammatory imitators of mycosis fungoides: histologic features

and utility of ancillary studies. Arch Pathol Lab Med. 2014; 138:1319-27.

Albrecht J, Fine LA, Piette W. Drug-associated lymphoma and pseudolymphoma: recognition and management.

Dermatol Clin. 2007; 25:233-44.

Rijlaardam JU, Meijer CJ, Willemze R. Differentiation between lymphadenosis benigna cutis and primary cutaneous

follicular center cell lymphomas. Cancer 1990:65:2301-6.

Ackerman AB, Briggs PL, Bravo F. Differential diagnosis in dermatopathology III. Philadelphia: Lea & Febiger; 1993.

Colli C, Leinweber B, Müllegger R, Chott A, Kerl H, Cerroni L. Borrelia burgdorferi associated lymphocytoma cutis:

clinicopathologic, immunophe- notypic, and molecular study of 106 cases. J Cutan Pathol 2004; 31:232-40.

Grange F, Wechsler J, Guillaume JC, Tortel J, Tortel MC, Audhuy B, et al. Borrelia burgdorferi associated lymphocytoma

cutis simulating a primary cutaneous large B-cell lymphoma. J Am Acad Dermatol 2002; 47:530-4.

Cerroni L, Borroni RG, Massone C, Chott A, Kerl H. Cutaneous B-cell pseudolymphoma at the site of vaccination.

Am J Dermatopathol 2007; 29:538-42.

Chong H, Brady K, Metze D, Calonje E. Persistent nodules at injection sites (aluminium granuloma)-clinicopathological

study of 14 cases with a diverse range of histological reaction patterns. Histopathology 2006; 48:182-8.

Kluger N, Vermeulen C, Mouguelet P, Cotten H, Koeb MH, Balme B, et al. Cutaneous lymphoid hyperplasia (pseudolymphoma)

in tattoos: a case series of seven patients. J Eur Acad Dermatol Venereol 2010; 24:206-13.

Published
2016-04-29
How to Cite
Teixeira, A. I., Gouveia, A. I., Brás, S., & Soares de Almeida, L. M. (2016). Cutaneous Lymphoid Infiltrates Simulating Cutaneous Lymphoma. Journal of the Portuguese Society of Dermatology and Venereology, 74(1), 15-24. https://doi.org/10.29021/spdv.74.1.511
Section
Continuous Medical Education