Infiltrados Linfocitários Cutâneos Simuladores de Linfoma
Resumo
Os pseudolinfomas cutâneos englobam um grupo heterogéneo de entidades clínico-patológicas que têm em comum o facto de simularem clínica ou histologicamente linfomas cutâneos primários. O seu diagnóstico é difícil pois não existem critérios precisos que diferenciem os infiltrados linfocitários reactivos dos infiltrados linfocitários neoplásicos. Os pseudolinfomas podem ser classificados de acordo com a predominância de linfócitos do tipo B versus T, ou agrupados segundo o tipo de linfoma cutâneo que mimetizam. O objectivo deste trabalho é discutir as pistas diagnósticas (histológicas e/ou clínicas) mais importantes na separação entre as várias entidades simuladoras de linfoma e os linfomas cutâneos que estas mimetizam.
Downloads
Referências
Cerroni L. Skin Lymphoma: The illustrated Guide. 4th ed. Oxford:John Wiley & Sons; 2014.
Ploysangam T, Breneman DL, Mutasim DF. Cutaneous pseudolymphomas. J Am Acad Dermatol. 1998; 38:877-95; quiz 896-7.
Heller P, Wieczorek R, Waldo E, Meola T, Buchness MR, Soter NA, et al. Chronic actinic dermatitis: an immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. Am J Dermatopathol 1994; 16:510-6.
Norris PG, Morris J, Smith NP, Chu AC, Hawk JL. Chronic actinic dermatitis: an immunohistologic and photobiologic
study. J Am Acad Dermatol 1989; 21:966-71.
Pacheco D, Fraga A, Travassos AR, Antunes J, Freitas J, Soares de Almeida L, et al. Actinic reticuloid imitating
Sézary syndrome. Acta Dermatovenerol Alp Pannonica Adriat. 2012; 21:55-7.
Knackstedt TJ, Zug KA. T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.
Contact Dermatitis. 2015; 72:65-74.
Gomez Orbaneja J, Iglesias Diez L, Sanchez Lozano JL, Conde Salazar L. Lymphomatoid contact dermatitis. Contact
Dermatitis. 1976; 2:139-43.
Martinez-Moran C, Sanz-Munoz C, Morales-Callaghan AM, Garrido-Rios AA, Torrero V, Miranda-Romero A.
Lymphomatoid contact dermatitis. Contact Dermatitis 2009; 60:53-5.
Kossard S. Unilesional mycosis fungoides or lymphomatoid keratosis? Arch Dermatol 1997; 133:1312-3.
Choi MJ, Kim HS, Kim HO, Song KY, Park YM. A case of lymphomatoid keratosis. Ann Dermatol. 2010; 22:219-22.
Fink-Puches R, Wolf P, Kerl H, Cerroni L. Lichen aureus. Clinicopathologic features, natural history, and relationship
to mycosis fungoides. Arch Dermatol 2008; 144:1169-73.
Citarella L, Massone C, Kerl H, Cerroni L. Lichen sclerosus with histopathologic features simulating early mycosis
fungoides. Am J Dermatopathol 2003; 25:463-5.
Cerroni L1, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H. Solitary skin lesions with histopathologic
features of early mycosis fungoides. Am J Dermatopathol. 1999; 21:518-24.
Beltraminelli H1, Leinweber B, Kerl H, Cerroni L. Primary cutaneous CD4+ small-/medium-sized pleomorphic
T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance?
A study of 136 cases. Am J Dermatopathol. 2009;31:317-22.
Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas.
Blood. 2005; 105:3768-85.
El-Shabrawi-Caelen L, Kerl H, Cerroni L. Lymphomatoid papulosis. Reappraisal of clinicopathologic presentation
and classification into subtypes A, B, and C. Arch Dermatol. 2004; 140:441.
Werner B, Massone C, Kerl H, Cerroni L. Large CD30-positive cells in benign, atypical lymphoid infiltrates of
the skin. J Cutan Pathol. 2008; 35:1100-7.
Hwong H, Jones D, Prieto VG, Schulz C, Duvic M. Persistent atypical lymphocytic hyperplasia following tick bite
in a child: report of a case and review of the literature. Pediatr Dermatol.2001; 18:481.
Gallardo F, Barranco C, Toll A, Pujol RM. CD30 antigen expression in cutaneous inflammatory infiltrates of scabies:
a dynamic immunophenotypic pattern that should be distinguished from lymphomatoid papulosis. J Cutan Pathol. 2002; 29:368.
Leinweber B, Kerl H, Cerroni L. Histopathologic features of cutaneous herpes virus infections (herpes simplex, herpes
varicella/zoster). A broad spectrum of presentations with common pseudolymphomatous aspects. Am J Surg Pathol. 2006; 30:50-5
Moreno-Ramírez D, García-Escudero A, Ríos-Martín JJ, Herrera-Saval A, Camacho F. Cutaneous pseudolymphoma in association with molluscum contagiosum in an elderly patient. J Cutan Pathol. 2003; 30:473-5.
Del Boz González J, Sanz A, Martín T, Samaniego E, Martínez S, Crespo V. Cutaneous pseudolymphoma associated
with molluscum contagiosum: a case report. Int J Dermatol. 2008; 47:502-4.
Massone C, Kodama K, Salmhofer W, Abe R, Shimizu H, Parodi A, et al. Lupus erythematosus panniculitis (lupus
profundus): clinical, histopathological, and molecular analysis of nine cases. J Cutan Pathol 2005; 32:396-404.
Bosisio F, Boi S, Caputo V, Chiarelli C, Oliver F, Ricci R, et al. Lobular panniculitic infiltrates with overlapping histopathologic features of lupus panniculitis (lupus profundus) and subcutaneous T-cell lymphoma: A conceptual and practical dilemma. Am J Surg Pathol. 2015;39:206-11.
Sarantopoulos GP, Palla B, Said J, Kinney MC, Swerdlow SM, Willemze R, et al. Mimics of cutaneous lymphoma:
report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am
J Clin Pathol. 2013; 139:536-51.
Breza TS Jr, Zheng P, Porcu P, Magro CM. Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine
therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response. J
Cutan Pathol. 2006; 33:522-8.
Crowson AN, Magro CM. Antidepressant therapy: a possible cause of atypical cutaneous lymphoid hyperplasia.
Arch Dermatol. 1995; 131:925-9.
Arps DP1, Chen S, Fullen DR, Hristov AC. Selected inflammatory imitators of mycosis fungoides: histologic features
and utility of ancillary studies. Arch Pathol Lab Med. 2014; 138:1319-27.
Albrecht J, Fine LA, Piette W. Drug-associated lymphoma and pseudolymphoma: recognition and management.
Dermatol Clin. 2007; 25:233-44.
Rijlaardam JU, Meijer CJ, Willemze R. Differentiation between lymphadenosis benigna cutis and primary cutaneous
follicular center cell lymphomas. Cancer 1990:65:2301-6.
Ackerman AB, Briggs PL, Bravo F. Differential diagnosis in dermatopathology III. Philadelphia: Lea & Febiger; 1993.
Colli C, Leinweber B, Müllegger R, Chott A, Kerl H, Cerroni L. Borrelia burgdorferi associated lymphocytoma cutis:
clinicopathologic, immunophe- notypic, and molecular study of 106 cases. J Cutan Pathol 2004; 31:232-40.
Grange F, Wechsler J, Guillaume JC, Tortel J, Tortel MC, Audhuy B, et al. Borrelia burgdorferi associated lymphocytoma
cutis simulating a primary cutaneous large B-cell lymphoma. J Am Acad Dermatol 2002; 47:530-4.
Cerroni L, Borroni RG, Massone C, Chott A, Kerl H. Cutaneous B-cell pseudolymphoma at the site of vaccination.
Am J Dermatopathol 2007; 29:538-42.
Chong H, Brady K, Metze D, Calonje E. Persistent nodules at injection sites (aluminium granuloma)-clinicopathological
study of 14 cases with a diverse range of histological reaction patterns. Histopathology 2006; 48:182-8.
Kluger N, Vermeulen C, Mouguelet P, Cotten H, Koeb MH, Balme B, et al. Cutaneous lymphoid hyperplasia (pseudolymphoma)
in tattoos: a case series of seven patients. J Eur Acad Dermatol Venereol 2010; 24:206-13.
Todos os artigos desta revista são de acesso aberto sob a licença internacional Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0).
