Nodulosis by the use of the Methotrexate in Patient with Rheumatoid Arthritis

  • Francisco Ronaldo Moura Filho Médico Residente/Resident, Dermatology, Serviço de Dermatologia do Hospital Universitário Getúlio Vargas (HUGV), Universidade Federal do Amazonas (UFAM), Manaus (AM), Brazil
  • Aline Guimarães Grana Médico Residente/Resident, Dermatology, Serviço de Dermatologia do Hospital Universitário Getúlio Vargas (HUGV), Universidade Federal do Amazonas (UFAM), Manaus (AM), Brazil
  • Aline do Amaral Silva Médico Residente/Resident, Dermatology, Serviço de Dermatologia do Hospital Universitário Getúlio Vargas (HUGV), Universidade Federal do Amazonas (UFAM), Manaus (AM), Brazil
  • Suzi Marla Carvalho Maron Médico Residente/Resident, Dermatology, Serviço de Dermatologia do Hospital Universitário Getúlio Vargas (HUGV), Universidade Federal do Amazonas (UFAM), Manaus (AM), Brazil
  • Bárbara Rodovalho Acadêmica de Medicina/Academic Medicine, Universidade Federal do Amazonas, Manaus (AM), Brazil
  • Fabio Francesconi Dermatologista Especialista pela Sociedade Brasileira de Dermatologia/Specialist in Dermatology, Mestre em Medicina Tropical/ Master in Tropical Medicine, Universidade do Estado do Amazonas, Manaus (AM)
DOI: https://doi.org/10.29021/spdv.74.4.679
Keywords: Arthritis, Rheumatoid, Methotrexate/adverse effects, Rheumatoid Nodule, Subcutaneous Tissue

Abstract

Extra-articular manifestations in patients with rheumatoid arthritis are common. Subcutaneous nodules appear in almost 8% of users of methotrexate with rheumatoid arthritis. Methotrexate, one of the recommended drugs in this disease, may cause unwanted effects such as accelerated nodulosis. This complication is an important differential diagnosis in subcutaneous nodules rapidly evolving in rheumatoid arthritis patients on methotrexate and TNF inhibitors. Early diagnosis is essential for a forehand treatment. We describe a case of accelerated nodulosis associated with the use methotrexate and etanercept in patients with rheumatoid arthritis.

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Published
2016-12-26
How to Cite
Moura Filho, F. R., Guimarães Grana, A., do Amaral Silva, A., Carvalho Maron, S. M., Rodovalho, B., & Francesconi, F. (2016). Nodulosis by the use of the Methotrexate in Patient with Rheumatoid Arthritis. Journal of the Portuguese Society of Dermatology and Venereology, 74(4), 387-390. https://doi.org/10.29021/spdv.74.4.679
Issue
Vol 74 No 4 (2016): Outubro - Dezembro
Section
Case Reports

All articles in this journal are Open Access under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).