Atypical Clinical Manifestations of Genital Herpes Simplex Virus Infection and Their Treatment

  • Pedro Miguel Garrido Clínica Universitária de Dermatologia de Lisboa, Centro Hospitalar Lisboa Norte, EPE (CHLN) – Lisboa, Portugal
  • João Borges-Costa Clínica Universitária de Dermatologia de Lisboa, Centro Hospitalar Lisboa Norte, EPE (CHLN) – Lisboa, Portugal; Unidade de Investigação em Dermatologia da Faculdade de Medicina da Universidade de Lisboa (FMUL) – Lisboa, Portugal; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
Keywords: AIDS-Related Opportunistic Infections, Antiviral Agents, Herpes Genitalis, Herpes Simplex, Sexually Transmitted Diseases, Viral


Genital herpes is a sexually transmitted infection with high global prevalence. Atypical clinical presentations of herpetic infection are rare but are becoming increasingly frequent due to the growing number of immunosuppressed patients. Therapy is challenging, with a longer treatment duration being frequently needed and an important resistance rate to the common anti-viral agents. Foscarnet and cidofovir are effective alternatives. In this article we review three atypical cutaneous presentations of herpetic infection, selected by their relevance in clinical practice: hypertrophic lesions, chronic ulcers and herpetic folliculitis.


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How to Cite
Garrido, P. M., & Borges-Costa, J. (2018). Atypical Clinical Manifestations of Genital Herpes Simplex Virus Infection and Their Treatment. Journal of the Portuguese Society of Dermatology and Venereology, 76(1), 65-70.
Grupo para o Estudo e Investigação das Doenças Sexualmente Transmissíveis (GEIDS