Extracutaneous Manifestations of Localized Scleroderma: A Review
Abstract
Morphea or localized scleroderma is a connective tissue disorder in which excess collagen deposition leads to the development of sclerotic lesions. Initially distinguished from systemic sclerosis by the absence of systemic manifestations, involvement limited to the skin and a relatively benign course, it is now known that localized sclerosis may be associated with multiple extracutaneous manifestations. This article reviews the musculoskeletal, neurological, ophthalmological, gastrointestinal, respiratory, cardiac and renal manifestations of this disease.
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