PROZONE PHENOMENON IN HIV NEGATIVE PATIENT
Abstract
Prozone phenomenon results from high antibody titers in patients with syphilis, causing a false negative Venereal Disease Research Laboratory (VDRL) results. We report a case of a 50-year-old female patient, with a chief complaint of diffuse, erythematous and asymptomatic lesions, conjunctival hyperemia in her left eye. The physical examination: maculopapular rash on the trunk, back, abdomen and face and right epitrochlear adenopathy. She brought general tests within normal limits and negative VDRL. We requested FTA-ABS IgG:+ and VDRL in diluted serum: 1:512. The optimal ratio of the antigen/antibody yields an insoluble precipitate that is visible, thus rendering the test positive. Thus, phenomenon prozon was confirmed.
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