Leprosy: From Antiquity to Our Times

  • Atanásio Máquina Interno da especialidade de Dermatologia e Venereologia do Hospital Central de Maputo, Moçambique
  • Alexandre Catarino Interno da especialidade de Dermatologia e Venereologia do Centro Hospitalar de Lisboa Ocidental - Hospital Egas Moniz, Lisboa, Portugal
  • Leandro Silva Interno da especialidade de Dermatologia e Venereologia do Centro Hospitalar de Lisboa Ocidental - Hospital Egas Moniz, Lisboa, Portugal
  • Goreti Catorze Assistente Hospitalar Graduado de Dermatologia e Venereologia, Serviço de Dermatologia, Centro Hospitalar de Lisboa Ocidental - Hospital Egas Moniz, Lisboa, Portugal
  • Lurdes Ferreira Assistente Hospitalar Graduado de Dermatologia e Venereologia, Serviço de Dermatologia, Centro Hospitalar de Lisboa Ocidental - Hospital Egas Moniz, Lisboa, Portugal
  • Isabel Viana Assistente Hospitalar Sénior de Dermatologia e Venereologia, Directora de Serviço, Centro Hospitalar Lisboa Ocidental - Hospital Egas Moniz, Lisboa, Portugal
Keywords: Leprosy/classification, Leprosy/diagnosis, Leprosy/epidemiology, Leprosy/etiology, Leprosy/history, Leprosy/therapy, Mozambique, Portugal

Abstract

Leprosy is an infectious disease whose causative agent are the bacillus Mycobacterium leprae and Mycobacterium lepromatosis. It preferably affects the skin and peripheral nerves. If left undiagnosed and not treated early, it can cause severe deformation and disability. Paradoxically, as treatment became curative, many specialist centers closed, which led to a reduced knowledge of the disease. With the increasing immigration to Europe of people from countries with high prevalence of leprosy, new cases have appeared in European countries namely in Portugal. A strong stigma based on the fear of contagion contributes to the prolonged suffering and delays in diagnosis and treatment of these patients. We make a brief review of this old disease from the ancient times to the present day.

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References

Ramos e Silva M, Ribeiro de Castro, MC. Mycobacterial infections. In: Bolognia JL, Schaffer JV, Cerroni L, edi- tors. Dermatology. 4th ed. Amsterdam: Elsevier; 2018. p.1296-1318.

Han XY, Seo YH, Sizer KC, Schoberle T, May GS, Spencer JS, et al. A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Pathol. 2008;130:856- 64. doi: 10.1309/AJCPP72FJZZRRVMM.

Pardillo FE, Fajardo TT, Abalos RM, Scollard D, Gelber RH. Methods for the classification of leprosy for treatment purposes. Clin Infect Dis. 2007;44:1096-9.

Organização Mundial da Saúde. Estratégia Global para Hanseníase 2016 – 2020 Manual operacional 2020. Genebra: OMS; 2019.

Providência P, Matos VMJ, Santos AL, Xavier S, Brás E, Quintais L, “Leprosaria Nacional. Modernidade e Ruína no Hospital-Colónia Rovisco Pais,” Dafine Ed., vol. 1, 2013.

Benchimol JL, Sá MR. Adolpho Lutz. Obra completa. Edi- tora FioCruz, vol. I. 2004.

Poiares-Baptista A. Comissão Internacional da Lepra - 1909. Rev Soc Port Dermatol Vnereol. 2013: 71:323.

Cruz A. O Hospital-Colónia Rovisco Pais: a última le- prosaria portuguesa e os universos contingentes da experiência e da memória. História, Ciências, Saúde- -Manguinhos.2018;16: 407–31.

Pinto C, Bordalo A, Albuquerque M, Nascimento M, Vicêncio P. Doenças de Declaração Obrigatória. Lisboa:Direção-Geral de Saúde;2016.

Organização Mundial da Saúde. Estratégia Global para Hanseníase 2016 – 2020 Manual operacional

Laureano A, Vieira R, Medeiros S, Assis-Pacheco F, Car- doso J. Incapacidade Funcional na Doença de Hansen - Estudo Retrospectivo, Descritivo e Analítico de 243 Doentes Tratados Antes e Depois da Terapêutica da OMS. Rev Soc Port Dermatol Venereol. 2013: 72:325- 31.

Singh P, Benjak A, Schuenemann VJ, Herbig A, Avanzi C, Busso P, et al. Insight into the evolution and origin of leprosy bacilli from the genome sequence of My- cobacterium lepromatosis. Proc Natl Acad Sci U S A. 2015;112:4459-64. doi: 10.1073/pnas.1421504112.

Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, et al. Susceptibility to leprosy is associated with PARK2 and PACRG. Nature. 2004;427:636-40.

Silva EA, Iyer A, Ura S, Lauris JR, Naafs B, Das PK, et al. Utility of measuring serum levels of anti-PGL-I antibody, neopterin and C-reactiveprotein in monitoring leprosy patients during multi-drug treatment and reactions.Trop

Med Int Health. 2007;12:1450-8.

Martiniuk F, Rao SD, Rea TH, Glickman MS, Giovinazzo J,

Rom WN,et al. Leprosy as immune reconstitution inflam- matory syndrome in HIV-positive persons. Emerg Infect Dis. 2007;13:1438-40. doi: 10.3201/eid1309.070301.

Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL. The continuing challenges of leprosy. Clin Microbiol Rev. 2006;19:338-81.

Suzuki K, Akama T, Kawashima A, Yoshihara A, Yotsu RR, Ishii N. Current status of leprosy: epidemiology, basic scien- ce and clinical perspectives. J Dermatol.2012;39:121-9. doi: 10.1111/j.1346-8138.2011.01370.x.

Srinivasan H. Prevention of Disabilities in Patients with Leprosy: A Pratical Guide. Geneva: World Health Orga- nization; 1993,

Ministério da Saúde, Guia de procedimentos técnicos: baciloscopia em hanseníase, vol. 7 edição. 2010.

Bührer-Sékula S. PGL-I leprosy serology. Rev Soc Bras Med Trop. 2008;41 Suppl 2:3-5.

Polycarpou A, Walker SL, Lockwood DN. A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum. Front Immunol. 2017;8:233. doi:10.3389/ fimmu.2017.00233.

Calonje JE, Brenn T, Lazar A, Billings S (Eds). McKee's Pathology of the Skin, 5th ed. Elsevier, 2019, pag. 899

World Health Organization. Regional Office for South- -East Asia; 2018. Guidelines for the diagnosis, treatment and prevention of leprosy. [access Jan 2019] Available from: https://apps.who.int/iris/handle/10665/274127.

Lambert SM, Alembo DT, Nigusse SD, Yamuah LK, Walker SL, Lockwood DN. A Randomized Controlled Double Blind Trial of Ciclosporin versus Prednisolone in the Ma- nagement of Leprosy Patients with New Type 1 Reaction, in Ethiopia. PLoS Negl Trop Dis. 2016;10:e0004502. doi: 10.1371/journal.pntd.0004502.

Bertolli J, Pangi C, Frerichs R, Halloran ME. A case-con- trol study of the effectiveness of BCG vaccine for pre- venting leprosy in Yangon, Myanmar. Int JEpidemiol. 1997;26:888-96.

Richardus R, Alam K, Kundu K, Chandra Roy J, Zafar T, Chowdhury AS,et al. Effectiveness of single-dose rifampi- cin after BCG vaccination to prevent leprosy in close con- tacts of patients with newly diagnosed leprosy: A cluster randomized controlled trial. Int J Infect Dis. 2019;88:65- 72. doi: 10.1016/j.ijid.2019.08.035.

Published
2020-01-11
How to Cite
Máquina, A., Catarino, A., Silva, L., Catorze, G., Ferreira, L., & Viana, I. (2020). Leprosy: From Antiquity to Our Times. Journal of the Portuguese Society of Dermatology and Venereology, 77(4), 323-338. https://doi.org/10.29021/spdv.77.4.1116
Section
Review Articles