NANOTECNOLIGIA EM DERMATOLOGIA
Resumo
Os últimos avanços em nanotecnologia revolucionaram os conceitos de prevenção e tratamento de algumas afeções cutâneas.
O uso de nanopartículas e micropartículas em cosmética e terapêutica preventiva é cada vez mais utilizado.
Menos conhecida mas muito investigada e utilizada é a aplicação de nano e micropartículas em materiais que contactam a pele, tais como vestuário, papel, equipamentos diversos, peles de animais, betão, vernizes, tintas, etc.,.
Downloads
Referências
Taylor E, Webster TJ. Reducing infections through nanotechnology and nanoparticles. Inf J Nanomedicine. 2011; 6:1463-73.
Dirk M, Elston MD. New and emerging infectious diseases. J Am Acad Dermatol. 2005; 52(6):1062-68.
Dirk M, Elston MD. Community-acquired methicillin-resistant Staphylococcus aureus. J Am Acad Dermatol.
; 56(1):1-16.
Jesline A, Neetu PJ, Narayanan M. Antimicrobial activity of zinc and titanium dioxide nanoparticles against
biofilm-producing methicillin-resistant Staphylococcus aureus. Appl Nanosci. 2014; 245-51.
Vincent MG, Neetu PJ, Narayanan PM, Vani C, Murugan S. In vitro study on the efficacy of zinc oxide and titanium dioxide nanoparticles against metallo beta-lactamase and biofilm producing Pseudomonas aeroginosa. J Appl Pharm Science. 2014; 4:41-46.
Seil JT. Reduced Staphylococcus aureus proliferation and biofilm formation on zinc oxide nanoparticles PVC composite surfaces. Acta Biomater. 2011; 7:2579-84.
Kwiecinski J, Eick S, Wojcik K. Effects of tea tree (Melaleuca alternifolia) oil on Staphylococcus aureus in biofilms and stationary growth phase. Int Antimicrob Agents. 2009; 33:343-7.
Uddin F. Environmental concerns in antimicrobial finishing of textiles. Inten. J Textile Science. 2014; 3:15-20.
Moore NM. Do nanoparticles present ecotoxicological risks for the health of the aquatic environment? Environ
In.t 2006; 13:4530-6.
Boxall ABA. Tiede K, Chaudhry Q, Engineered nano materials in soils and water. How do they behave and could they pose a risk to human health? Nanomedicina. 2007;2:919-27.
Russel AD, Hugo WB. Antimicrobial activity and action of silver. Prog Med Chem. 1994; 31:351-71.
Lansdown AB, Silver I. Its antimicrobial properties and mechanism of action. J Wound Care. 2002; 11:125-30.
Kalbassi M, Salari-joo H, Johari A. Toxicity of silver nanoparticles in aquatic ecosystems: salinity as the main cause in reducing toxicity. Iranian J Toxicol. 2011; 5:436-43.
Eckelman MJ, Graedel TE. Silver emissions and their environmental impacts: a multilevel assessment. Environ Sci Thechnol. 2007; 41:6282-9.
Jia Z, Shen D, Xu W. Synthesis and antibacterial activities of quaternary ammonium salt of chitosan. Carbohydr Res. 2001; 333(1):1-6.
Zabielska-Matejuk J. Antifungal properties of new quaterny ammonium compounds in relation to their surface
activity. Wood Sci Techn. 2005; 39:235-43.
Vilayakumar R, Kannan VV, Sandle T, Manoharan C. In vitro antifungal efficacy of biguanides and quaternary
ammonium compounds against cleanroom fungal isolates. PDA J Pharm Sci Technol. 2012; 66:236-42.
Oblak E, Piecuch A, Krasowska A, Luczincki J. Antifungal activity of gemini of quaternary ammonium salts. Macrobiol Res. 2013; 168:680-8.
Akiyama H, Yamasaki O, Kanzaki H, Tada J, Arata J. Effects of zinc oxide on the attachment of Staphylococcus
aureus strains. J Dermatol Sci. 1998; 17:67-74.
Olst RF. Management of atopic dermatitis: are there differences between children and adults? J Eur Acad Dermatol Venereol. 2014; 28(suppl 3):5-8.
Wollenberg A, Seba A, Antal AS. Immunological and molecular targets of atopic dermatitis treatment. Br J
Dermatol. 2014; 170(suppl.s1):7-11.
Maillard JY. Antimicrobial biocides in the healthcare environment: efficacy, usage, policies, and perceived problems. Ther Clin Risk Manag. 2005; 1:307-20.
Cho YS, Schiller, Oh KH. Antibacterial effects of green tea polyphenols on clinical isolates of methicillin-resistant Staphylococcus-resisten. Curr Microbiol. 2008; 57:542-6.
Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (tea tree oil) suppresses inflammatory mediator production by activated human monocytes. Inflamm Res. 2000;49:619-26.
Carson CF, Riley TV, Cookson BD. Efficacy and safety of tea tree oil as a topical antimicrobial agent, J Hosp Infection 1998; 40:175-79.
Gordon NC. Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against
clinical isolates of Stenotrophomonas maltophilia. Int J Antimicrob Agents. 2010; 36:129-31.
Corson T, Crews CM. Molecular understanding and modern application of traditional medicines; triumphus and trials. Cell. 2007; 180:769-74.
Xue-JuanLi, Yong-Yu Zhang. Western healers in traditional Chinese medicine. EMBO Rep. 2008:112-1.
Tiwari TP, Bharti SK, Kaur HD, Dikshit RP, Hoondal GS. Synergistic antimicrobial activity of tea & antibiotics. Indian
J Med Res. 2005; 122:80-4.
Low WL, Martin C, Hill DJ, Kenward MA. Antimicrobial efficacy of silver ions combination with tea tree oi against Pseudomonas aeroginosa, Staphylococcus aureus and Candida albicans. Int J Antimicrob Agents. 2011; 37:162-5.
Schrmitz J, Schafer, Bruhl C. Risk assessment of herbicides for the common buttercup Ranunculus acris in field
margins - an experimental field study. SETAC World Congress 2012, Berlin, Germany.
Hahn M et al. Caterpillars and protection goals: the role of field margins as habitats and the effect of pesticide
applications. SETAC World Congress 2012, Berlin, Germany.
Zaganas I, Kapetanaki S, Mastorodemos V, Kanavouras K, Colosio C, Wilks MF, et al. Linking pesticide exposure
and dementia: what is the evidence? Toxicology. 2013; 307:3-11.
EPA Directive. [Available at:http//www.epa.gov/pesticides/health/mosquitoes/ai-_insectrp.htm.
CDC Directive. World Available t:http//www.cdc.gov/ncidod/dvbid/westnile/RepellentUpdates.htm.
Abou-Donia MB, Wilmarth KR, Jensen KF, Oehme FW, Kurt TL. Neurotoxicity resulting from coexposure to pyridostigmine bromide, deet, and permethrin: implications of Gulf War chemical exposures. J Toxicol Environ Health.
; 48:35.
Badolo A, Ilboudo-Sanogo E, Ouédraogo AP, Costantini C. Evaluation of the sensitivity of Aedes aegypti and Anopheles gambiae complex mosquitoes to two insect repellents; DEET and KBR 3023. Trop Med Int Health. 2004;9:330.
Caroll JF, Benante JP, Kramer M, Lohmeyer KH, Lawrence K. Formulations of DEET, Picaridin and IR3535 applied to
skin repel nymphs of the lone star tick (Acari: Ixodidae) for 12 hours. J Med Entomol. 2010; 47:699-704.
Constantini C, Badolo A, Ilboudo-Sanogo E. Field evaluation of the efficacy and persistence of insect repellents
DEET, IR3535 and KBR 3023 against Anopheles gambiae complex and other afrotopical vector mosquitoes. Trans R Soc Trop Med Hyg. 2004; 98:644-52.
Goddart J, Sharz R. Bed bugs (Climex lectularius) and clinical consequences of their bites. JAMA. 2009;
:1358-66.
Doggest SL, Dwyer DE, Peñas PF, Russell RC. Bed bugs: clinical relevance and control options. Clin Microbiol Rev.
; 25:164-92.
Külcü Çakmak S, Gönül M, Oğuz ID, Yayla D, Gül U, Köse K. Demographical, laboratory and associated findings
in patients with perniosis. J Eur Acad Dermatol Venereol. 2014; 28:891-4.
Patra AK, Das AL, Ramaddasan P. Diltiazem vs nifedipine in chilblains: a clinical trial. Indian J Dermatol Venereol
Leprol. 2003; 69:209-11.
Aguirre-Crespo F, Vergara-Galicia J, Villalobos-Molina R, Javier López-Guerrero J, Navarrete-Vázquez G, Estrada-
Soto S. Ursolic acid mediates the vasorelaxant activity of Lepechinia caulenses via NO release in isolated rat thoracic aorta. Life Sci. 2006;79:1062-8.
Vergara-Galicia J, Aguirre-Crespo F, Castillo-España P, Arroyo-Mora A, López-Escamilla AL, Villalobos-Molina
R, et al. Micropropagation and vasorelaxant activity of Laelia autumnalis (orchidaceae). Nat Prod Res. 2010;24:106-14.
Vergara GJ et al. Vasorelaxant effect of Laelia speciosa and Laelia anceps: two orchids as potential sources for isolation of bioactive molecules. L Appl Pharm Sci. 2013; 7:34-7.
Vergara-Galicia J, Ortiz-Andrade R, Rivera-Leyva J, Castillo-España P, Villalobos-Molina R, Ibarra-Barajas M, et al. Vasorelaxant and antihypertensive effects of methanolic extract roots of Laelia anceps are mediated by calcium-channel antagonism. Fisioterapia. 2010;81:350-7.
Hernandez-Abreu O, Castillo-España P, León-Rivera I, Ibarra-Barajas M, Villalobos-Molina R, González-Christen
J, et al. Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated
by NO/cGMP pathway and potassium channel opening. Biochem Pharmacol. 2009; 78:54-61.
Cunha GH, de Moraes MO, Fechine FV, Frota Bezerra FA, Silveira ER, Canuto KM, et al. Vasorelaxant and antihypertensive effects of methanolic fraction of the essential oil of Alpinia zerumber. Vascul Pharmacol. 2013;
:337-45.
Torres-Piedra M, Figueroa M, Hernández-Abreu O, Ibarra-Barajas M, Navarrete-Vázquez G, Estrada-Soto S. Vasorelaxant effect of flavonoids through calmodulin inhibition. Bioorg Med Chem. 2011; 19:542-6.
Rendon Vallejo P, Hernández-Abreu O, Vergara-Galicia J, Millán-Pacheco C, Mejía A, Ibarra-Barajas M, et al. Ex
vivo study of vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa. J Nat
Prod. 2012; 75:2241-5.
Li L, Zhang B, Tao Y, Wang Y, Wei H, Zhao J, et al. Dl-3-n-buthylpftalide protects endothelial cells against oxidative
/ nitrosative stress mithochondrial damage and subsequent cell death - after oxygen glucose deprivation in vitro. Brain Res. 2009; 1290:91-101.
Vergara GJ, Ángel JR, Adrián TS, Francisco AC, Anuar SG, Samuel ES, et al. Vasorelaxant activity of extracts obtained from Apium graveolens; Possible source for vasorelaxant molecules isolation with potential antihypertensive
effect. Asian Pac J Trop Biomed. 2013; 3:776-9.
Zhang T. 3-n-butylphtalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-
-regulation in diabetic rats. Neurol Res. 2010; 32:390-6.
Alavi A, Sibbald RG, Mayer D, Goodman L, Botros M, Armstrong DG, et al. Diabetic foot ulcers. Part I. Pathophysioloy
and prevention. J Am Acad Dermatol. 2014; 70:21-43.
Alavi A, Sibbald RG, Mayer D, Goodman L, Botros M, Armstrong DG, et al. Diabetic foot ulcers. Part II. Management.
J Am Acad Dermatol. 2014; 70:1-20.
Edmonds M. Diabetic foot ulcers: practical treatment recommendations. Drugs. 2006; 66:913-29.
Mazen S. Diabetic foot infection. Am Farm Physician. 2008; 78:71-9.
Liao SJ, Lin JW, Pei Z, Liu CL, Zeng JS, Huang RX. Enhanced angiogenesis with dl-3n-butylphtalide treatment
after focal cerebral ischemia in RHRSP. Brain Res. 2009; 1289:69-78.
Yang Y, Sang W, Zhou M, Ren G. Phenolic composition and antioxidant activities of 11 celery cultivars. J Food
Sci. 2010; 75:9-13.
Jung WS et al. In vitro antioxidant activity, total phenolics and flavonoids from celery (Apium graveolens) leaves. J
Med Plants Res. 2011; 5:7022-30.
Kolarovic J, Popovic M, Zlinská J, Trivic S, Vojnovic M. Antioxidant activities of celery and parsley juices in rats treated with doxorubicin. Molecules. 2010; 15:6193-204.
Nagella P, Ahmad A, Kim SJ, Chung IM. Chemical composition, antioxidant activity and larvicidal effects of
essential oil from leaves of Apium graveolens. Immunopharmacol Immunotoxicol. 2012; 34:205-9.
Fazel S, Singia RK. Review on the pharmacognostical pharmacological characterization of Apium graveolens
Linn. Indo Global J Pharmaceut Seimas 1012; 2:36-42.
Zhang L, Yu WH, Wang YX, Wang C, Zhao F, Qi W, et al. DL-3-n-butylphtalide an anti-oxidant agent, prevents
neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging
and histological assessment. Curr Neurovasc Res. 2012; 9:167-75.
Xiong N, Huang J, Chen C, Zhao Y, Zhang Z, Jia M, et al. Dl-3-n-butylphtalide, a natural antioxidant, protects
dopamina neurons in rotenone models for Parkinson's disease. Neurobiol Aging. 2012; 33:1777-91.
Li J, Li Y, Ogle M, Zhou X, Song M, Yu SP, et al. Dl-3-n-butylphtalide prevents neuronal cell death after focal
cerebral ischemia in mice via the JNK pathway. Brain Res 2010; 1369:216-20.
Kangyong L, Huang J, Chen R, Zhang T, Shen L, Yang J, et al. Protection against neurotoxicity by a autophagic
mechanism. Braz J Med Biol Res. 2012; 45:401-7.
Zhang T, Yan W, Li Q, Fu J, Liu K, Jia W, et al. 3-n-butylphtalide (NBP) attenuated neuronal autophagy and
amyloid-beta expression in diabetic mice subjected to brain ischemia. Neurol Res 2011; 33:396-4.
Huang JZ, Chen YZ, Su M, Zheng HF, Yang YP, Chen J, et al. dl-3-n-butylphtalide prevents oxidative damage and
reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson's diease Neurosci Lett. 2010;
:89-94.
Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, et al. L-3-n-butylphtalide improves cognitive impairment
and reduces amyloid-beta in a transgenic model of Alzheimer´s disease. J Neurosci. 2010; 30:8180-9.
Ford I, Cotter MA, Cameron NE, Greaves M. The effects of treatment with alpha-lipoid acid or evening primrose
oil on vascular hemostatic and lipid risk factors, blood flow and peripheral nerve conduction in streptozocin-
-diabetic rat. Metabolism. 2001; 50:868-75.
Gutierrez RM et al. In vitro and in vivo antidiabetic and antiglycation properties of Aipum graveolens in type
and 2 diabetic rat. Intern J Pharmacol. 2014;10:368-79.
Todos os artigos desta revista são de acesso aberto sob a licença internacional Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0).
