URTICÁRIA DE CONTACTO INDUZIDA POR FÁRMACOS

Ana Gameiro; Miguel Gouveia; Leonor Ramos; Margarida Gonçalo

doi:10.29021/spdv.73.4.489

Ana Gameiro Interna de Dermatologia e Venereologia/Resident of Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Portugal
Miguel Gouveia Interna de Dermatologia e Venereologia/Resident of Dermatology and Venereology, Serviço de Dermatologia e Venereologia do Centro Hospitalar e Universitário de Coimbra, Portugal
Leonor Ramos Assistente Hospitalar de Dermatovenereologia/Consultant of Dermatology and Venereology, Serviço de Dermatologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Margarida Gonçalo Assistente Graduada Sénior, Chefe de Serviço, Assistente Convidada da Faculdade de Medicina da Universidade de Coimbra / Consultant Chief, Invited Professor of the Medical School of Coimbra University, Portugal

DOI: https://doi.org/10.29021/spdv.73.4.489

Palavras-chave: Anafilaxia/induzida quimicamente, Dermatite Alérgica de Contacto, Dermatite de Contacto, Hipersensibilidade a Medicamentos, Urticária/induzida quimicamente

Resumo

A dermatite de contacto inclui qualquer reação inflamatória da pele, secundária a contato direto ou indireto entre esta e agentes agressores. A expressão clínica mais comum é o eczema, ou outros padrões resultantes de reações retardadas, mas reações imediatas como a urticária de contacto podem também ocorrer. O espectro de manifestações clínicas por urticária de contacto é amplo. Na sua forma mais limitada, manifesta-se por urticária localizada à área de contacto entre o alergénio e a pele ou mucosa, e nos casos de apresentações mais exuberantes, podem surgir lesões urticariformes generalizadas, angioedema, ou mesmo anafilaxia. Em teoria, todos os fármacos tópicos podem ser responsáveis por urticária de contacto, e vários fármacos foram já descritos como indutores. As moléculas implicadas podem ser os princípios ativos ou os excipientes, por via de mecanismos imunológicos ou não. Os autores apresentam uma revisão dos diferentes fármacos descritos na urticária de contacto, dando enfâse à urticária de contacto das mucosas e em contexto profissional.

Downloads

Não há dados estatísticos.

Referências

Giménez-Arnau A, Maibach H. Contact urticaria syndrome: Definition, history, etiology, and relevance. In:

Gimenez-Arnau AM, Maibach HI, editors. Contact Urticaria Syndrome. Leiden: CRC Press; 2014. p.1-8.

Aalto-Korte Kand Suomela S. Contact Urticaria Syndrome: Epidemiology and Occupational Relevance. In:

Gimenez-Arnau AM, Maibach HI, editors. Contact Urticaria Syndrome. Leiden: CRC press; 2014. p.9-14.

Giménez-Arnau A. Contact urticaria and the environment. Rev Environ Health. 2014; 29:207-15.

Gimenez-Arnau A, Maurer M, De La Cuadra J, Maibach H. Immediate contact skin reactions, an update of

contact urticaria, contact urticaria syndrome and protein contact dermatitis - “A Never Ending Story”. Eur J Dermatol.

; 20:552-62.

Amaro C, Goossens A. Immunological occupational contact urticaria and contact dermatitis from proteins: a

review. Contact Dermatitis. 2008; 58:67-75.

Gonçalo M, Gonçalo S, Moreno A. Immediate and delayed hypersensitivity to chlorocresol. Contact Dermatitis.

; 17:46-7.

Jovanovic M, Karadaglic D, Brkic S. Contact urticaria and allergic contact dermatitis to lidocaine in a patient

sensitive to benzocaine and propolis. Contact Dermatitis. 2006; 54:124-6.

Grob J, Pommier G, Robaglia A, Collet-Villette A, Boneradi JJ. Contact urticaria from rifamycin. Contact Dermatitis. 1987; 16:284-5.

Park M-R, Kim D-S, Kim J, Ahn K. Anaphylaxis to topically applied sodium fusidate. Allergy Asthma Immunol

Res. 2013; 5:110-2.

Doutre M-S. Occupational contact urticaria and protein contact dermatitis. Eur J Dermatol. 2005; 15:419-24.

Williams J, Lee A, Metheson M, Frowen K, Noonan A, Nixon R. Occupational contact urticaria: Australian

data. Br J Dermatol. 2008; 159:125-31.

Martin S. Contact dermatitis: from pathomechanisms to immunotoxicology. Exp Dermatol. 2012; 21:382-9.

Filipe P. Urticária crónica: novas perspectivas terapêuticas. Rev Soc Port Dermatol Venereol. 2015; 73:55-60.

Co-Minh H, Demoly P, Guillot B, Raison-Peyron N. Anaphylactic shock after oral intake and contact urticaria to

polyethylene glycols. Allergy. 2007; 62:92-3.

Brinca A, Cabral R, Gonçalo M. Contact allergy to local anaesthetics-value of patch testing with a caine mix in the

baseline series. Contact Dermatitis. 2013; 68:156-62.

Knowles SR, Shear NH. Anaphylaxis from bacitracin and polymyxin B (Polysporin) ointment. Int J Dermatol. 1995;

:572-3.

Mancuso G, Masara N. Contact urticaria and severe anaphylaxis from rifamycin SV. Contact Dermatitis.

; 27:124-5.

Kim E, Maibach H. Contact urticaria. In: Greaves M, Kaplan A, editors. Urticaria and angioedema. New York:

Marcel Dekker, Inc.; 2004. p.149-69.

Maucher O, Fuchs A. Contact urticaria caused by skin test in pyrazolone allergy. Hautartz. 1983; 34:383-6.

Lombardi P, Giorgini S, Achille A. Contact urticaria from aminophenazone. Contact Dermatitis. 1983; 9:428-9.

Jonker M, Bruynzeel D. Anaphylactic reaction by patch testing with diclofenac. Contact Dermatitis. 2003; 49:114-5.

Piñol J, Carapeto F. Contact urticaria to etofenamate. Contact Dermatitis. 1984; 11:133.

Suzuki T, Kawada A, Hashimoto Y, Isogai R, Aragane Y, Tezuka T. Contact urticaria due to ketoprofen. Contact

Dermatitis. 2003; 48:284-5.

Escribano M, Muñoz-Bellido F, Velazquez E, Delgado J, Serrano P, Guardia J, et al. Contact urticaria due to aescin.

Contact Dermatitis. 1997; 37:233.

Waton J, Boulanger A, Trechot PH, Schmutz JL, Barbaud A. Contact urticaria from Emla cream. Contact Dermatitis.

; 51:284-7.

Channual J, Wu J, Zachary C. Localized contact urticaria caused by lidocaine/tetracaine peel. Arch Dermatol.

; 145.

Caballero M, Lukawaska J, Dugué P. A hidden case of perioperative anaphylaxis. J Invest Clin Immunol. 2010;

:353-4.

Adachi A, Fukunaga A, Hayashi K, Horikawa T. Anaphylaxis to polyvinylpirrolidone after vaginal application

of povido-iodine. Contact Dermatitis. 2003; 48:133-6.

Antunes J, Kochuyt A-M, Ceuppens JL. Perioperative allergic reactions: Experience in a Flemish referral centre.

Allergol et Immunopathol. 2014; 42:348-54.

Keni NN, Aras M, Chitre V. Chlorhexidine allergy due to topical application. Indian J Dent Res. 2012; 23:674-6.

Aranda A, Mayorga C, Ariza A, Doña I, Rosado A, Blanca-Lopez N, et al. In vitro evaluation of IgE-mediated

hypersensitivity reactions to quinolones. Allergy. 2011; 66:247-54.

Saito M, Nakada T. Contact urticaria syndrome from eye drops: levofloxacin hydrate ophthalmic solution. J Dermatol. 2013; 40:130-1.

Muñoz-Bellido FJ, Beltrán A, Bellido J. Contact urticaria due to cyclopentolate hydrochloride. Allergy Asthma Immunol Res. 2000; 55:198-9.

Roesch A, Haegele T, Vogt T, Babilas P, Landthaler M, Szeimies RM. Severe contact urticaria to guar gum included

as gelling agent in a local anaesthetic. Contact Dermatitis. 2005; 52:307-8.

Wittczak T, Dudek W, Walusiak-Skorupa J, Swierczynska-Machura D, Pałczynski C. Chlorhexidine-still an underestimated allergic hazard for health care professionals. Occup Med.2013; 63:301-5.

Moder B, Kranke B. Anaphylactic reaction to formaldehyde. Allergy. 2001; 56:263-4.

Michavila Gomez A, Belver Gonzalez M, Alvarez N, Giner Muñoz M, Hernando Sastre V, Porto Arceo J, et al.

Perioperative anaphylactic reactions: Review and procedure protocol in paediatrics. Allergol Immunopathol.

; 43:203-14.

Choi IS, Han E-R, Lim S-W, Lim S-R, Kim J-N, Park S-Y, et al. Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses. Allergy, Asthma Immunol Res. 2010; 2:114-22.

Fellinger C, Wantke F, Hemmer W, Sesztak-greinecker G, Wöhrl S. The rare case of a probably true IgE-mediated

allergy to local anaesthetics. Case Rep Med. 2013; 2013:201586.

Couto M, Gaspar A, Piedade S, Arêde C, Menezes M, Sousa MJ, et al. IgE-mediated metamizol allergy and the

usefulness of the cellular allergen stimulation test. Eur Ann Allergy Clin Immunol. 2012; 44:113-6.

Mihyhara H, Koga T, Imayama S, Hori Y. Ocupational contact urticaria syndrome from cefotiam hydrochloride.

Contact Dermatitis. 1993; 29:210-1.

Condé-Salazar L, Guimaraens D, González M a, Mancebo E. Occupational allergic contact urticaria from amoxicillin. Contact Dermatitis. 2001; 45:109.

Galvez Lozano JM, Alcantara M, De San Pedro BS, Quiralte J, Caba I. Occupational contact urticaria caused by

donepezil. Contact Dermatitis. 2009; 61:176.

Schena D, Barba A, Costa G. Occupational contact urticaria due to cisplatin. Contact Dermatitis. 1996;

:220.

Nunez Orjales R, Carballas Vázquez C, Carballada González F, Boquete Pars M. 2-Phenoxyethanol-induced

contact urtcaria and anaphylaxis. J Investig Allergol Clin Immunol. 2010; 20:354-5.

Barbaud A, Gonçalo M, Bircher A, Bruynzeel D. Guidelines for performing skin tests with drugs in the investigation

of cutaneous adverse drug reactions. Contact Dermatitis. 2001; 45:321-8.

Brockow K, Garvey LH, Aberer W, Atanaskovic-Markovic M, Barbaud A, Bilo MB, et al. Skin test concentrations for

systemically administered drugs-an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy. 2013;

:702-12.

Kim JE, Kim SH, Choi GS, Ye YM, Park HS. Detection of specific IgE antibodies to cefotiam-HSA conjugate by

ELISA in a nurse with occupational anaphylaxis. Allergy. 2010; 65:791-2.

Kim JE, Kim SH, Jin HJ, Hwang EK, Kim JH, Ye YM, et al. IgE sensitization to cephalosporins in health care

workers. Allergy Asthma Immunol Res. 2012; 4:85-91.

Sanz M, Gamboa P, Weck A. In vitro tests: Basophil activation tests. In: Pichler W, editor. Drug Hypersensitivity.

Basel: Karger; 2007. p. 391-402.