Chronic Hand Eczema Due to Contact Allergy to Sesquiterpene Lactones and Parthenolide

  • Leonor Lopes Interna do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Clinica Universitária de Dermatologia, Hospital de Santa Maria (Centro Hospitalar Lisboa Norte - CHLN), Lisboa, Portugal
  • A I. Gouveia Interna do Internato Complementar de Dermatologia e Venereologia/Resident, Dermatology and Venereology, Clinica Universitária de Dermatologia, Hospital de Santa Maria (Centro Hospitalar Lisboa Norte - CHLN), Lisboa, Portugal
  • Teresa E. Correia Assistente Hospitalar Graduada de Dermatologia e Venereologia/Senior Consultant, Dermatology and Venereology, Clinica Universitária de Dermatologia, Hospital de Santa Maria (CHLN), Lisboa, Portugal
Keywords: Dermatitis, Allergic Contac, Hand Dermatoses, Plant Extracts, Plants, Sesquiterpenes, Tanacetum parthenium

Abstract

Allergic contact dermatitis to plants can assume different clinical patterns. We report a 63-year-old female patient with chronic hand dermatitis. Given the clinical suspicion of allergic contact dermatitis, patch tests were performed with the Baseline series of the GPEDC and a plants series which showed positivity to sesquiterpene lactone mix 0.1% pet (++) and parthenolide 0.1% pet (++) at day D2 and D4. These test results allowed the diagnosis of contact allergy to parthenolide that was related to occupational exposure Chamaemelum fuscatum during gardening. We emphasize the importance of a meticulous clinical history to increase the level of suspicion of Allergic contact dermatitis and evaluate the relevance of a positive patch test to sesquiterpene lactone and parthenolide as the etiology in chronic hand dermatitis.

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References

Jean L. Bolognia, Dermatology. 3rd ed. Amsterdam: Elsevier;

Gonçalo M. Dermatosis profesionales por plantas e maderas.

In: Conde-Salazar Gómez L, Ancona Alayón A, editores. Dermatosis Profesionales. Barcelona: Menarini Área Científica; 2000. p.121-8.

De D, Jindal R, Kanwar AJ. Contact dermatitis to parthenium simulating lichen nitidus. Indian J Dermatol Venereol Leprol 2010; 76:286-8.

Chamaemelum fuscatum [consultado a 21 de Abril de 2016]. Disponível em: http://flora-on.pt/index.php? q=Chamaemelum+fuscatum

Sharma VK, Verma P. Parthenium dermatitis in India: Past, present and future. Indian J Dermatol Venereol Leprol 2012; 78:560-8.

Killoran C. Two cases of compositae dermatitis exacerbated

by moisturizer containing feverfew. Dermatitis. 2007; 18:225-9.

Paulsen E, Christense LP, Fretté XC, Andersen KE. Patch test reactivity to feverfew – containing creams in feverfew allergic patients. Contact Dermatitis 2010; 63:146-50.

Orion, E, Paulsen E, Andersen KE, Menné T. Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix. Contact Dermatitis. 1998; 38:207-8.

Paulsen E, Andersen KE, Hausen BM. An 8-year experience with routine SL mix patch testing supplemented with Compositae mix in Denmark. Contact Dermatitis. 2001; 45:29-35.

Bong JL, English JS, Wilkinson SM. Diluted Compositae mix versus sesquiterpene lactone mix as a screening agent for Compositae dermatitis: a multicentre study. Contact Dermatitis. 2001; 45:26-8.

Published
2016-10-15
How to Cite
Lopes, L., Gouveia, A. I., & E. Correia, T. (2016). Chronic Hand Eczema Due to Contact Allergy to Sesquiterpene Lactones and Parthenolide. Journal of the Portuguese Society of Dermatology and Venereology, 74(3), 261-264. https://doi.org/10.29021/spdv.74.3.595
Section
Grupo Português de Estudo das Dermites de Contacto (GPEDC)