Dermatoses with Minimal Histological Changes: Making the Invisible Visible

  • Katarina Kieselová Serviço de Dermatologia, Centro Hospitalar de Leiria, Leiria, Portugal
  • Luís Soares-de-Almeida Serviço de Dermatologia, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal; Clínica Universitária de Dermatologia de Lisboa, Universidade de Lisboa, Faculdade de Medicina, Lisboa, Portugal
Keywords: Biopsy, Skin/pathology, Skin Diseases/pathology


Skin biopsies remain an indispensable tool for aiding dermatologists in accurate diagnosis and treatment. However, some clinically evident skin diseases show histological picture resembling normal skin when examined after preparation with hematoxylin and eosin (H&E). In order to establish the correct diagnosis, clinicopathological correlation is essential, together with further investigations such as special stains and immunohistochemistry techniques. Hereby, we discuss the most relevant of these “invisible” dermatoses on H&E, and include strategy for approaching such cases.


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How to Cite
Kieselová, K., & Soares-de-Almeida, L. (2020). Dermatoses with Minimal Histological Changes: Making the Invisible Visible. Journal of the Portuguese Society of Dermatology and Venereology, 78(2), 141-146.
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