FAST AND SIMULTANEOUS GROWTH OF MULTIPLE MELANOCYTIC NEVI ASSOCIATED WITH SEMINOMA

Abstract

Potential effects of pregnancy-associated hormones, endogenous and exogenous hormones on melanocytic nevi have been known for years. A 35-year-old man presented with a 6 month history of fast and simultaneous growth of previous, multiple melanocytic nevi located on the trunk, associated with increased levels of beta-human chorionic gonadotropin derived from testicular seminoma. After radical orchiectomy and adjuvant radiotherapy the tumor marker became undetectable. Without tumor relapse or further growth or other changes in skin lesion after 3 years of follow-up. We propose that in our patient, β-HCG derived from seminoma increased the growth pattern of previous nevi, a rarely described association.