Paediatric Lymphomatoid Papulosis: Diagnostic Challenges and Follow-up
Abstract
Lymphomatoid papulosis is a rare primary T-cell lymphoproliferative cutaneous disorder, mostly affecting adults. Although histopathology suggests a malignant disease, in most cases, lymphomatoid papulosis is a self-limited condition with a good prognosis. We describe the case of an 8-year-old boy, otherwise healthy, who presented with a 4-6 week history of polymorphic cutaneous lesions disseminated over the whole body. Histology and immunohistochemistry confirmed the diagnosis of lymphomatoid papulosis type A. The authors discuss the main challenges in follow-up, treatment and the risk of progression of lymphomatoid papulosis to secondary lymphomas in this age group.
Downloads
References
Macaulay WL. Lymphomatoid papulosis. Arch Dermatol.
; 97:23-31.
Kempf W, Kazakov D, Belousova I, Mitteldorf C, Kerl K.
Paediatric cutaneous lymphomas: a review and comparison
with adult counterparts. J Eur Acad Dermatol Venereol.
; 9:1696-709.
Willemze R, Jaffe E, Meijer C, Cerroni L, Berti E, Swerdlow
SH,et al. WHO-EORTC classification for cutaneous lymphomas.
Blood. 2005; 105:3768-85.
Wieser I, Wohlmuth C, Nunez C, Duvic M. Lymphomatoid
papulosis in children and adolescents: a systematic review.
Am J Clin Dermatol. 2016; 17:319-27.
Ruffieux C, Delacrétaz J. Lymphomatoid papulosis in an
-month-old child. 9-year remission. Dermatologica.
; 171:368-70.
Nijsten T, Curiel-Lewandrowski C, Kadin ME. lymphomatoid
papulosis in children: a retrospective cohort study of
cases. Arch Dermatol. 2004; 140:306-12.
Miquel J, Fraitag S, Hamel-Teillac D, Molina T, Brousse N,
de Prost Y, et al. Lymphomatoid papulosis in children: a
series of 25 cases. Br J Dermatol. 2014; 171:1138-46.
Zirbel G, Gellis S, Kadin M, Esterly N. Lymphomatoid papulosis
in children. J Am Acad Dermatol. 1995; 33:741-8.
Martorell-Calatayud A, Hernández-Martín A, Colmenero
I, Vañó-Galván S, López-Obregón C, Armand A, et al.
Lymphomatoid papulosis in children: report of 9 cases
and review of the literature. Actas Dermosifiliogr. 2010;
:693-701
De Souza A, El-Azhary RA, Camilleri MJ, Wada DA,
Appert DL, Gibson LE. In search of prognostic indicators
for lymphomatoid papulosis: a retrospective study of 123
patients. J Am Acad Dermatol. 2012; 66:928.
Cordel N, Tressières B, D'Incan M. Frequency and risk factors
for associated lymphomas in patients with lymphomatoid
papulosis, French Study Group on Cutaneous
Lymphoma. Oncologist. 2016; 21:76-83.
Boccara O, Blanche S, de Prost Y, Brousse N, Bodemer C.
Fraitag S. Cutaneous hematologic disorders in children.
Pediatr Blood Cancer. 2012; 58:226-32.
Yip L, Darling S, Orchard D. Lymphomatoid papulosis in
children: experience of five cases and the treatment efficacy
of methotrexate. Australas J Dermatol. 2011; 52:279-
Van Neer F, Toonstra J, Van Voorst Vader P, Willemze R, Van
Vloten W. Lymphomatoid papulosis in children: a study of
children registered by the Dutch Cutaneous Lymphoma
Working Group. Br J Dermatol. 2001; 144:351-4.
Queller JN, Bognet RA, Kozic H, Lee JB, Sahu J, Hyde PM.
A case of mycosis fungoides and lymphomatoid papulosis
occurring simultaneously in a child. J Clin Aesthet Dermatol.
; 5:46-8.
All articles in this journal are Open Access under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
