Insights into CANDLE Syndrome

Keywords: Hereditary Autoinflammatory Diseases, Lipodystrophy, Proteasome Endopeptidase Complex/genetics, Skin Diseases/ genetics, Syndrome


Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction. This review chronicles the recognition of CANDLE syndrome, the developments in the understanding of the pathomechanism, genetic background, and the emerging therapeutic strategies of this condition.


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How to Cite
Kieselová, K., Santiago, F., & Henrique, M. (2020). Insights into CANDLE Syndrome. Journal of the Portuguese Society of Dermatology and Venereology, 78(1), 17-24.
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