Fotodermatoses Autoimunes Parte I - Fisiopatologia e Diagnóstico

Virginia Coelho de Sousa; Rita Ramos Pinheiro; Filipa Rocha Páris; Margarida Apetato; Gabriela Marques Pinto

doi:10.29021/spdv.75.4.876

Virginia Coelho de Sousa Serviço de Dermatologia, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
Rita Ramos Pinheiro Serviço de Dermatologia, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
Filipa Rocha Páris Serviço de Dermatologia, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
Margarida Apetato Serviço de Dermatologia, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
Gabriela Marques Pinto Serviço de Dermatologia, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal

DOI: https://doi.org/10.29021/spdv.75.4.876

Keywords: Dermatitis, Photoallergic/diagnosis, Photoallergic/etiology, Immune System, Photosensitivity Disorders/ diagnosis, Photosensitivity Disorders/etiology, Ultraviolet Rays

Abstract

The autoimmune photodermatoses are a group of heterogeneous idiopathic dermatoses physiopathologically characterized by underexplored immune mechanisms, usually involving an immune reaction against an unknown antigen. This group includes five different clinical entities – polymorphous light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, solar urticaria - some potentially severe with great impact in patients’ quality of life. The pathogenesis of the autoimmune photodermatosis seems to be realated with the formation of photoallergens in response to sunlight. The hypersensibility mechanism varies between the different diseases. The diagnosis depends on the recognition of the clinical presentation. Phototests confirm the diagnosis and allow the determination of the responsible radiation and limiar dose of induction. In an era where photodermatology has been losing its importance, we propose to revise the pathogenesis and diagnosis of autoimmune photodermatoses.

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