A Síndrome de CANDLE
Resumo
A síndrome de CANDLE, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature, é uma doença auto-inflamatória crónica, fisiopatologicamente condicionada pela disfunção intracelular do proteasoma/imunoproteasoma. Esta revisão descreve o reconhecimento da síndrome de CANDLE, os desenvolvimentos na compreensão do seu mecanismo patológico, os antecedentes genéticos e as estratégias terapêuticas emergentes para esta condição.
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Referências
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